Optimization of a green extraction technique for kratom (ketum) leaf extract via Accelerated Solvent Extraction: phytochemical profiles, cytotoxicity, and antinociceptive activity

Kratom (Mitragyna speciosa Korth.) has gained increasing scientific interest for its potential in pain management and addiction treatment. This study employs a green chemistry approach to optimize the extraction of kratom leaves by using Accelerated Solvent Extraction (ASE) with an ethanol–water bin...

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Main Authors:	Rusmadi, Nurul Najwa, Karunakaran, Thiruventhan, Ramli, Faiqah, Ismail, Intan Safinar, Santhanam, Rameshkumar, Yuvenesan Jagabalan, J. D., Abu Bakar, Mohamad Hafizi, Muhamad, Azira, Ramanathan, Surash
Format:	Article
Published:	American Chemical Society 2025
Subjects:	Pharmacology Pharmacology (medical)
Online Access:	http://psasir.upm.edu.my/id/eprint/123095/ https://pubs.acs.org/doi/10.1021/acsptsci.5c00647
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