Role of miR-101-3p/RAP1B axis and insulin protection in glucose-induced stress in HK-2 cell model for diabetic kidney disease

Role of miR-101-3p/RAP1B axis and insulin protection in glucose-induced stress in HK-2 cell model for diabetic kidney disease

Proximal tubular cell (PTC) injury is a critical driver of diabetic kidney disease (DKD). This study aimed to characterize the molecular response of HK-2 PTCs to acute glucotoxicity, focusing on the miR-101-3p/RAP1B axis, insulin-mediated protection, and the primary mechanisms of cell death. HK-2 ce...

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Bibliographic Details
Main Authors: Devaraju, Premala, C. Thambiah, Subashini, Ling, King Hwa, Zahari Sham, Siti Yazmin
Format: Article
Language:en
Published: Springer 2026
Subjects:
Biophysics
Biochemistry
Online Access:http://psasir.upm.edu.my/id/eprint/122926/1/122926.pdf
http://psasir.upm.edu.my/id/eprint/122926/
https://link.springer.com/article/10.1007/s12013-025-01950-9?error=cookies_not_supported&code=d88f3a91-18e7-487e-94ba-c937e4580989
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http://psasir.upm.edu.my/id/eprint/122926/1/122926.pdf
http://psasir.upm.edu.my/id/eprint/122926/
https://link.springer.com/article/10.1007/s12013-025-01950-9?error=cookies_not_supported&code=d88f3a91-18e7-487e-94ba-c937e4580989

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