Discovery of new non-symmetrical heterocyclic pentanoid derivatives targeting metastatic triple-negative breast cancer

This study describes the synthesis and structure-activity relationship (SAR) analysis of non- symmetrical heterocyclic pentanoid derivative as potential anti-cancer agents. The lead compound, 5d, exhibited potent (IC50 = 0.38 ± 0.05 μM) and selective (Selectivity Index: 2–9) growth inhibitory effect...

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Main Authors:	Khor, Poh Yen, Stanslas, Johnson, Rasol, Nurulfazlina Edayah, Chan, Kok Meng, Mock, Phooi Yan, Lam, Kok Wai
Format:	Article
Language:	en
Published:	Elsevier 2025
Subjects:	Biochemistry Molecular Medicine
Online Access:	http://psasir.upm.edu.my/id/eprint/122602/1/122602.pdf http://psasir.upm.edu.my/id/eprint/122602/ https://linkinghub.elsevier.com/retrieve/pii/S0960894X25001416
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