Inhibition of junctional protein disruption by 2,4,6-trihydroxy-3-geranyl acetophenone in lipopolysaccharide-induced endothelial hyperpermeability via GEF-H1/RhoA/ROCK pathway

Inhibition of junctional protein disruption by 2,4,6-trihydroxy-3-geranyl acetophenone in lipopolysaccharide-induced endothelial hyperpermeability via GEF-H1/RhoA/ROCK pathway

2,4,6-Trihydroxy-3-geranyl acetophenone (tHGA) is a bioactive phloroglucinol compound found in the leaves of Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley. Our previous study has proven that tHGA exhibited significant in vitro barrier protective effects against lipopolysaccharide (LPS) inducti...

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Bibliographic Details
Main Authors: Chan, Yee Han, Liew, Kong Yen, Rullah, Kamal, Harith, Hanis Hazeera, Tan, Ji Wei, Israf, Daud Ahmad, Shaari, Khozirah, Marcus, Mexmollen, Tham, Chau Ling
Format: Article
Language:en
Published: Springer Science and Business Media Deutschland GmbH 2025
Subjects:
Pharmacology
Online Access:http://psasir.upm.edu.my/id/eprint/122264/1/122264.pdf
http://psasir.upm.edu.my/id/eprint/122264/
https://link.springer.com/article/10.1007/s00210-025-04627-5?error=cookies_not_supported&code=96c4d06a-8b67-45a2-b6d7-75a846085bd9
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http://psasir.upm.edu.my/id/eprint/122264/1/122264.pdf
http://psasir.upm.edu.my/id/eprint/122264/
https://link.springer.com/article/10.1007/s00210-025-04627-5?error=cookies_not_supported&code=96c4d06a-8b67-45a2-b6d7-75a846085bd9

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