Safety profile of sikamat virus and its oncolytic potential in leukemic cells and cancer stem cells

Leukaemia remains a global health concern. The oncotherapy resistance of leukaemia might be due to the existence of cancer stem cell populations. This study investigated the therapeutic potential of Sikamat virus (PRV7S), a Pteropine orthoreovirus, as an oncolytic virus against acute myeloid leukaem...

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Main Authors:	Siew, Zhen Yun, Ong, Ghee Khang, Wong, Siew Tung, Leong, Pooi Pooi, Tan, Boon Shing, Leong, Chee-Onn, Chupri, Juita, Fang, Chee-Mun, Voon, Kenny
Format:	Article
Language:	en
Published:	Nature Research 2025
Online Access:	http://psasir.upm.edu.my/id/eprint/120642/1/120642.pdf http://psasir.upm.edu.my/id/eprint/120642/ https://www.nature.com/articles/s41598-025-96061-z?error=cookies_not_supported&code=0c10635b-4c6e-4193-93fb-fc40a9916c9b
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