Association between Prolactin Receptor (PRLR) gene polymorphisms and litter size in Katjang-Boer hybrid goats
Goat fertility is essential for farm productivity and economic viability. This study investigates the association between Prolactin Receptor (PRLR) gene polymorphism and litter size in Katjang-Boer hybrid goats. DNA from 43 goats was analyzed using five primers targeting different regions of the PRL...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Malaysian Society of Animal Production
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/117501/1/117501.pdf http://psasir.upm.edu.my/id/eprint/117501/ https://mjas.my/mjas-v2/rf/pages/viewpaper.php?id=352 |
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| Summary: | Goat fertility is essential for farm productivity and economic viability. This study investigates the association between Prolactin Receptor (PRLR) gene polymorphism and litter size in Katjang-Boer hybrid goats. DNA from 43 goats was analyzed using five primers targeting different regions of the PRLR gene. Polymerase chain reaction (PCR) and Single-Strand Conformation Polymorphism (SSCP) were employed to detect genetic variation. The association between litter size, breeding year, and PRLR polymorphism was determined using Kruskal-Wallis and Mann-Whitney U tests. Results indicate a significant association between PRLR gene polymorphisms in intron 1 and intron 2 with litter size (p < 0.05). Specifically, the AH genotype in intron 1 was significantly associated with larger litter sizes (1.58 ± 0.19, p < 0.05). No significant associations were found for exon 9 and 3’UTR regions. Breeding year also significantly influenced litter size, with the highest numbers observed in the later parity. These findings provide insights for improving farm productivity through genetic selection. |
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