Brain insulin resistance in down syndrome: involvement of PI3K-AKT/MTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target
Down syndrome (DS) is the most common genetic cause of intellectual impairment, characterised by an extra copy of chromosome 21. After the age of 40, DS individuals are highly susceptible to accelerated ageing and the development of early-onset Alzheimer-like neuropathology. In the context of DS, th...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | en |
| Published: |
Elsevier
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115959/1/115959.pdf http://psasir.upm.edu.my/id/eprint/115959/ https://linkinghub.elsevier.com/retrieve/pii/S0006291X2401249X |
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