FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT
Currently, immunotherapy is seen to be the most effective cancer treatment. This is especially true while treating chronic lymphocytic leukemia (CLL), a slow-growing B-lymphocyte neoplasm that gradually compromises the immune system. Mathematical modeling is acknowledged as a key technique for analy...
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World Scientific
2025
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| author | Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S. |
| author2 | 57205596279 |
| author_facet | 57205596279 Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S. |
| author_sort | Jan R. |
| building | UNITEN Library |
| collection | Institutional Repository |
| content_provider | Universiti Tenaga Nasional |
| content_source | UNITEN Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Currently, immunotherapy is seen to be the most effective cancer treatment. This is especially true while treating chronic lymphocytic leukemia (CLL), a slow-growing B-lymphocyte neoplasm that gradually compromises the immune system. Mathematical modeling is acknowledged as a key technique for analyzing theoretical and practical challenges in this field of cancer research and others. We were inspired to develop a mathematical model because of its dearth in investigations of chemotherapy-induced immunotherapy for CLL. This study effort formulates the dynamics of lymphocytic leukemia utilizing fractional calculus to conceptualize the complex processes of this viral illness. The basic idea of fractional calculus has been shown using the Atangana-Baleanu framework. For the suggested model's chaotic and dynamic behavior, a new numerical approach is described. We inspect the stability and convergence of the suggested numerical technique in our work. The fluctuation of various system input elements has demonstrated the oscillatory and chaotic behavior of the system. Moreover, we have demonstrated how the suggested mechanism of lymphocytic leukemia infection is affected by fractional order. Through numerical simulations, the most important input parameters are emphasized, and the policymakers are given control intervention suggestions. ? 2024 World Scientific. All rights reserved. |
| format | Article |
| id | my.uniten.dspace-37111 |
| institution | Universiti Tenaga Nasional |
| publishDate | 2025 |
| publisher | World Scientific |
| record_format | dspace |
| spelling | my.uniten.dspace-371112025-03-03T15:47:36Z FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S. 57205596279 37059587300 57891336000 57997905800 36903183800 15051122700 23028598900 57215716650 Chemotherapy Diseases Dynamics Atanganum-baleanu derivative B lymphocytes Cancer research Chaotic behaviour Chaotic phenomenon Chronic lymphocytic leukemias Fractional calculus Fractional dynamics Lymphocytic leukemia Stability analyze Numerical methods Currently, immunotherapy is seen to be the most effective cancer treatment. This is especially true while treating chronic lymphocytic leukemia (CLL), a slow-growing B-lymphocyte neoplasm that gradually compromises the immune system. Mathematical modeling is acknowledged as a key technique for analyzing theoretical and practical challenges in this field of cancer research and others. We were inspired to develop a mathematical model because of its dearth in investigations of chemotherapy-induced immunotherapy for CLL. This study effort formulates the dynamics of lymphocytic leukemia utilizing fractional calculus to conceptualize the complex processes of this viral illness. The basic idea of fractional calculus has been shown using the Atangana-Baleanu framework. For the suggested model's chaotic and dynamic behavior, a new numerical approach is described. We inspect the stability and convergence of the suggested numerical technique in our work. The fluctuation of various system input elements has demonstrated the oscillatory and chaotic behavior of the system. Moreover, we have demonstrated how the suggested mechanism of lymphocytic leukemia infection is affected by fractional order. Through numerical simulations, the most important input parameters are emphasized, and the policymakers are given control intervention suggestions. ? 2024 World Scientific. All rights reserved. Final 2025-03-03T07:47:36Z 2025-03-03T07:47:36Z 2024 Article 10.1142/S0218348X24400127 2-s2.0-85182568820 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182568820&doi=10.1142%2fS0218348X24400127&partnerID=40&md5=aa327246d97a20b176779b4d25dc5f0c https://irepository.uniten.edu.my/handle/123456789/37111 32 2 2440012 World Scientific Scopus |
| spellingShingle | Chemotherapy Diseases Dynamics Atanganum-baleanu derivative B lymphocytes Cancer research Chaotic behaviour Chaotic phenomenon Chronic lymphocytic leukemias Fractional calculus Fractional dynamics Lymphocytic leukemia Stability analyze Numerical methods Jan R. Razak N.N.A. Alyobi S. Khan Z. Hosseini K. Park C. Salahshour S. Paokanta S. FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT |
| title | FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT |
| title_full | FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT |
| title_fullStr | FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT |
| title_full_unstemmed | FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT |
| title_short | FRACTIONAL DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH THE EFFECT OF CHEMOIMMUNOTHERAPY TREATMENT |
| title_sort | fractional dynamics of chronic lymphocytic leukemia with the effect of chemoimmunotherapy treatment |
| topic | Chemotherapy Diseases Dynamics Atanganum-baleanu derivative B lymphocytes Cancer research Chaotic behaviour Chaotic phenomenon Chronic lymphocytic leukemias Fractional calculus Fractional dynamics Lymphocytic leukemia Stability analyze Numerical methods |
| url_provider | http://dspace.uniten.edu.my/ |