Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor
Diagnosis; Fiber optics; Optical fibers; Optical sensors; Proteins; Viruses; Clinical management; Dimensional changes; Fundamental concepts; Optical based sensors; Quantitative assessments; Recombinant antibody; Tapered optical fiber sensors; Tapered optical fibers; Fibers
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Elsevier B.V.
2023
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| author | Mustapha Kamil Y. Abu Bakar M.H. Mustapa M.A. Yaacob M.H. Abidin N.H.Z. Syahir A. Lee H.J. Mahdi M.A. |
| author2 | 57212503622 |
| author_facet | 57212503622 Mustapha Kamil Y. Abu Bakar M.H. Mustapa M.A. Yaacob M.H. Abidin N.H.Z. Syahir A. Lee H.J. Mahdi M.A. |
| author_sort | Mustapha Kamil Y. |
| building | UNITEN Library |
| collection | Institutional Repository |
| content_provider | Universiti Tenaga Nasional |
| content_source | UNITEN Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Diagnosis; Fiber optics; Optical fibers; Optical sensors; Proteins; Viruses; Clinical management; Dimensional changes; Fundamental concepts; Optical based sensors; Quantitative assessments; Recombinant antibody; Tapered optical fiber sensors; Tapered optical fibers; Fibers |
| format | Article |
| id | my.uniten.dspace-23889 |
| institution | Universiti Tenaga Nasional |
| publishDate | 2023 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | my.uniten.dspace-238892023-05-29T14:52:50Z Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor Mustapha Kamil Y. Abu Bakar M.H. Mustapa M.A. Yaacob M.H. Abidin N.H.Z. Syahir A. Lee H.J. Mahdi M.A. 57212503622 57193327503 56538400900 55002214500 57202624319 26532043800 57190622221 7005348074 Diagnosis; Fiber optics; Optical fibers; Optical sensors; Proteins; Viruses; Clinical management; Dimensional changes; Fundamental concepts; Optical based sensors; Quantitative assessments; Recombinant antibody; Tapered optical fiber sensors; Tapered optical fibers; Fibers The surge of Dengue cases around the globe has intensified the demand for a reliable diagnostic method. The work demonstrates, to the best of our knowledge, the first label-free optical based sensor for detection of Dengue II E proteins. This was achieved by utilizing tapered optical fiber that has been functionalized with complementary recombinant antibodies. The fundamental concept of the sensor relies on the interaction between strong evanescent waves resulting from the dimensional change of the fiber and immune complex formed on the surface of the fiber when the virus is present. Sensitivity and detection limit values obtained with the sensor setup are 5.02 nm/nM and 1 pM, respectively, with a standard deviation value of no more than �0.4. The compact and rapid sensor is a viable alternative for label-free and quantitative assessment of the infection, which may assist in providing better clinical management and understanding of the disease. � 2017 Elsevier B.V. Final 2023-05-29T06:52:50Z 2023-05-29T06:52:50Z 2018 Article 10.1016/j.snb.2017.11.005 2-s2.0-85034051919 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034051919&doi=10.1016%2fj.snb.2017.11.005&partnerID=40&md5=d15f5c0d89d3071561ae9cc0ccff22b3 https://irepository.uniten.edu.my/handle/123456789/23889 257 820 828 All Open Access, Green Elsevier B.V. Scopus |
| spellingShingle | Mustapha Kamil Y. Abu Bakar M.H. Mustapa M.A. Yaacob M.H. Abidin N.H.Z. Syahir A. Lee H.J. Mahdi M.A. Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor |
| title | Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor |
| title_full | Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor |
| title_fullStr | Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor |
| title_full_unstemmed | Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor |
| title_short | Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor |
| title_sort | label-free dengue e protein detection using a functionalized tapered optical fiber sensor |
| url_provider | http://dspace.uniten.edu.my/ |