The role of maternal serum and breast milk adipokines in determining infant adiposity development
Obesity has been a great concern in Malaysia since there is an alarming increase in its prevalence. Besides storing fat, adipose tissue is also an endocrine organ that secretes a large number of adipokines. Pregnancy, a state with metabolic changes, has been recognized as a critical period for the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/5802/1/FH02-FSK-18-13123.pdf http://eprints.unisza.edu.my/5802/ |
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| Summary: | Obesity has been a great concern in Malaysia since there is an alarming increase in its prevalence. Besides
storing fat, adipose tissue is also an endocrine organ that secretes a large number of adipokines. Pregnancy, a
state with metabolic changes, has been recognized as a critical period for the development of infant adiposity as
a result of imbalanced adipokines production. Hence, the Universiti Sains Malaysia Pregnancy Cohort Study
was established to investigate the role of maternal serum and breast milk adipokines (adiponectin and leptin) in
determining the first year infant adiposity development. This study was conducted from April 2010 until
December 2012. A total of 155 healthy pregnant mothers aged 19 to 40 years were recruited at first and second
trimester of pregnancy in Kelantan, Malaysia. Data collection was consisted of maternal sociodemography,
anthropometry and clinical biochemistry analysis; and infant‟s anthropometry and feeding patterns. Fasting
serum samples were taken during pregnancy for adiponectin and leptin levels analyses. Breast milk samples
were collected at birth and 2 months postpartum. Data collection was performed at second and third trimester of
pregnancy, continued with follow-up visits at birth, 2 months, 6 months and 12 months postpartum. Multiple
linear regression (MLR) analyses were performed to examine the associations of maternal serum and breast milk
adiponectin and leptin on infant adiposity development. MLR models showed that in the first year of age, as
maternal serum and breast milk adiponectin increased, infant weight, BMI-for-age Z-scores, abdominal
circumference and triceps skinfold significantly decreased (p<0.05). Maternal serum and/or breast milk
adiponectin were associated with the first year infant adiposity development. The favourable results of breast
milk adiponectin indicated the potential role of breastfeeding practice in the prevention of obesity since
infanthood. |
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