Pharmacogenomic profiling of ABCB1 and CES1 in atrial fibrillation patients on dabigatran from a multiethnic Malaysian cohort

Direct oral anticoagulants (DOACs) are preferred for atrial fibrillation (AF) due to their efficacy and safety, though response variabilities raises concerns about fixed-dose regimens. This study investigates the association between ABCB1 and CES1 genetic polymorphisms with Dabigatran trough drug le...

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Main Authors:	Shirley Tan, Siang Ning, Edmund Sim, Ui Hang, Timothy Adrian, Jinam, Melissa Lim, Siaw Han, Cassandra Chee, Sheau Mei, Lawrence, Anchah, Saiful Shakirin, Rosli, Beatrice Bangie, Desmond Sateng, Jerry, Gerunsin, Tiong, Lee Len, Alan Fong, Yean Yip
Format:	Article
Language:	en
Published:	Springer Nature 2026
Subjects:	QH426 Genetics R Medicine (General) RM Therapeutics. Pharmacology
Online Access:	http://ir.unimas.my/id/eprint/51472/1/Tan%20SSN%202026.pdf http://ir.unimas.my/id/eprint/51472/ https://www.nature.com/articles/s41598-026-38856-2 https://doi.org/10.1038/ s41598-026-38856-2
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