Efficacy of IV Ketamine in Refractory/Super-Refractory Status Epilepticus: A Systematic Review and Meta-Analysis
Background and Objectives Intravenous ketamine is increasingly used for refractory and super-refractory status epilepticus(RSE/ SRSE), yet its efficacy and optimal use remain uncertain. We therefore aimed to synthesize the available evidence to quantify the effectiveness of ketamine in achieving...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
American Academy of Neurology
2026
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/51372/3/Efficacy%20of%20IV%20Ketamine%20in%20Refractory%20-%20Copy.pdf http://ir.unimas.my/id/eprint/51372/ https://www.neurology.org/doi/abs/10.1212/CPJ.0000000000200584 https://doi.org/10.1212/CPJ.0000000000200584 |
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| Summary: | Background and Objectives
Intravenous ketamine is increasingly used for refractory and super-refractory status epilepticus(RSE/
SRSE), yet its efficacy and optimal use remain uncertain. We therefore aimed to synthesize the
available evidence to quantify the effectiveness of ketamine in achieving seizure cessation and to
explore differences in treatmentcharacteristics between patients who respond and those who do not.
Methods
We conducted a systematic review and meta-analysis to estimate the pooled seizure cessation
rate associated with intravenous ketamine. Secondary analyses compared ketamine initiation
timing, dosing, and infusion duration between patients who achieved seizure cessation (responders) and those who did not (nonresponders). |
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