Epstein-Barr Virus in Nasopharyngeal Carcinoma: Molecular Mechanisms and Oncogenic Drivers
Background: Nasopharyngeal carcinoma (NPC) is a malignancy strongly associated with Epstein-Barr virus (EBV) infection. EBV is detected in nearly all non-keratinizing NPC cases and plays a central role in tumor initiation, progression, and immune evasion. Objective: To review the key molecular mec...
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| Main Authors: | , |
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| Format: | Article |
| Language: | en |
| Published: |
Japan University of Health Sciences & Japan International Cultural Exchange Foundation (JICEF)
2025
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/50465/1/5Mustapha.pdf http://ir.unimas.my/id/eprint/50465/ https://www.imj-1994.com/past-issues/ |
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| Summary: | Background: Nasopharyngeal carcinoma (NPC) is a malignancy strongly associated with Epstein-Barr virus (EBV) infection.
EBV is detected in nearly all non-keratinizing NPC cases and plays a central role in tumor initiation, progression, and immune evasion.
Objective: To review the key molecular mechanisms by which EBV contributes to NPC development, with a focus on viral
oncogenes, host-pathogen interactions, and potential therapeutic implications.
Method: A literature-based review of current evidence from molecular oncology, virology, and NPC-focused clinical studies
was conducted to outline EBV-driven oncogenic pathways and their role in NPC.
Conclusion: Understanding EBV-driven molecular mechanisms in NPC provides critical insights into the disease's etiology
and highlights novel opportunities for early diagnosis, prognostic biomarker development, and targeted therapy. |
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