Glial cells missing 1 triggers gliosis and angiogenesis after neonatal brain injury
The glial cells missing (gcm) protein in Drosophila plays a crucial role in the cell fate switch in the nervous system and in induction of glial cell differentiation. However, the functions of the mammalian homologue Gcm1 in normal neural development and pathological conditions remain elusive. Here,...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Elsevier Inc.
2025
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/50141/1/PIIS2589004225021212.pdf http://ir.unimas.my/id/eprint/50141/ https://www.sciencedirect.com/science/article/pii/S2589004225021212 https://doi.org/10.1016/j.isci.2025.113860 |
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| Summary: | The glial cells missing (gcm) protein in Drosophila plays a crucial role in the cell fate switch in the nervous system and in induction of glial cell differentiation. However, the functions of the mammalian homologue Gcm1 in normal neural development and pathological conditions remain elusive. Here, we report that Gcm1 was upregulated in Nestin+ cells immediately after neonatal brain injury, followed by accumulation of GFAP+ and Olig2+ cells in the penumbra region. Injury-induced upregulation of Lif gene was mediated, at least in part, by the demethylation activity of Gcm1. In addition, Gcm1 strongly induced angiogenesis in the injury lesion as well as in the developing brain via vascular endothelial growth factor A and C activity. Lack of Gcm1-mediated angiogenesis could be a major cause of the dysplasia in placental labyrinths found in Gcm1–/– embryos, leading to embryonic lethality. Our data suggest that Gcm1 triggers both gliosis and angiogenesis after brain injury and could be a target for therapeutic intervention. |
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