Neurobiology of chronic caffeine use and withdrawal : Mechanisms, effects and implications

Caffeine is the most widely consumed psychoactive substance worldwide and is increasingly being explored for its potential pharmacological applications, including in neurodegenerative diseases, cognitive enhancement, and pain modulation. However, chronic caffeine use leads to neuroadaptive changes t...

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Bibliographic Details
Main Authors: Yu Zhao, Lee, Ker Ni, Chua, Fui Ling, Voon, Chau Ling, Tham, Yu Cheng, Ho, Ming Tatt, Lee
Format: Article
Language:en
Published: Elsevier Ltd. 2026
Subjects:
Online Access:http://ir.unimas.my/id/eprint/50077/3/Neurobiology%20of%20chronic%20caffeine%20-%20Copy.pdf
http://ir.unimas.my/id/eprint/50077/
https://www.sciencedirect.com/science/article/pii/S027869152500585X
https://doi.org/10.1016/j.fct.2025.115817
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