Cardiac Autonomic Dysfunction in Obstructive Sleep Apnea : The Hidden Role of Vitamin D Deficiency
Obstructive sleep apnea (OSA) is a common sleep-breathing disorder, affecting an estimated 9–38% of adults worldwide, with prevalence increasing in parallel with rising obesity rates and aging population [1]. While men are still more likely to be diagnosed with OSA, this condition is becoming more...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
John Wiley & Sons Australia, Ltd
2025
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/49767/1/J%20Evidence%20Based.pdf http://ir.unimas.my/id/eprint/49767/ https://onlinelibrary.wiley.com/doi/10.1111/jebm.70071 https://doi.org/10.1111/jebm.70071 |
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| Summary: | Obstructive sleep apnea (OSA) is a common sleep-breathing
disorder, affecting an estimated 9–38% of adults worldwide, with prevalence increasing in parallel with rising obesity rates and aging population [1]. While men are still more likely to be diagnosed with OSA, this condition is becoming more common in women [2]. Coronary artery disease (CAD), a common complication of OSA, is driven by a combination of intermittent hypoxia, metabolic dysfunction, and systemic inflammation, which together accelerate atherosclerosis [3]. This underscores the importance of identifying modifiable factors to mitigate cardiovascular risks in these patients. A key mechanism linking OSA to heightened cardiovascular risks in CAD is cardiac autonomic dysfunction, characterized by increased sympathetic activity and reduced parasympathetic tone. These alterations can be assessed
through heart rate variability (HRV), a well-established predictor of adverse cardiovascular outcomes. |
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