A Metabolic Activation Mechanism of 7H-Dibenzo[c,g]carbazole via O-Quinone. Part 2: Covalent Adducts of 7H-Dibenzo[c,g]carbazole-3,4-dione with Nucleic Acid Bases and Nucleosides

7H-Dibenzo[c,g]carbazole (DBC) is a potent multispecies, multisite carcinogen present in the environment. The metabolic activation pathways of DBC are not completely known. It is hypothesized that DBC may be metabolically activated by oxidation to the reactive Michael acceptor o-quinones, which can...

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Bibliographic Details

Main Authors:	Weiling, Xue, Angela, Siner, Mark, Rance, Koka, Jayasimhulu, Glenn, Talaska, David, Warshawsky
Format:	Article
Language:	en
Published:	ACS Publications 2002
Subjects:	Q Science (General) QD Chemistry RZ Other systems of medicine
Online Access:	http://ir.unimas.my/id/eprint/47899/3/A%20Metabolic%20Activation%20Mechanism%20of%20-%20Copy.pdf http://ir.unimas.my/id/eprint/47899/ https://pubs.acs.org/doi/10.1021/tx0200156 https://doi.org/10.1021/tx0200156
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