Factors associated with in-hospital mortality among infective endocarditis patients
Introduction: Despite recent advancements in the diagnosis and management of infective endocarditis (IE), it is associated with substantial morbidity and mortality. Our study objective is to determine the factors associated with in-hospital mortality in IE patients among the local population....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Malaysian Medical Association
2023
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/45215/1/Factors%20associated.pdf http://ir.unimas.my/id/eprint/45215/ https://www.e-mjm.org/2023/v78n6/infective-endocarditis.pdf |
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| Summary: | Introduction: Despite recent advancements in the diagnosis
and management of infective endocarditis (IE), it is
associated with substantial morbidity and mortality. Our
study objective is to determine the factors associated with
in-hospital mortality in IE patients among the local
population.
Materials and Methods: All IE patients who were diagnosed
with definite or possible IE and were treated at Sarawak
Heart Centre from 1st January 2020 to 31st December 2022
were recruited. We examined the demographic features of
the subjects and the factors that contributed to in-hospital
mortality. Multivariate logistic regression was used to
analyse the associated factors and in-hospital mortality.
Results: Our study population comprised a total of 37
patients with a mean age of 46.4 years and male
predominance. The in-hospital mortality rate of IE in this
study was 44.4%. Haemodynamic instability and anaemia
were found to be strong predictors of IE survival outcome,
with an odds ratio of 51.5 and 35.7 respectively. Patients with
vascular phenomenon and heart failure were at 10.5- and
6.0-times higher odds of dying, however, these two
associations were found to be not statistically significant.
Conclusion: The in-hospital mortality due to IE in our study
was among the highest in developing countries. Factors of
hypotension and optimal response to individual
hemodynamic parameters may confer lower mortality. While
anaemia is demonstrable as a risk factor for inpatient
mortality, a target has yet to be reasonably established |
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