“A stitch in time saves nine” : managing congenital nephrotic syndrome in resource-limited circumstances
We report a case of congenital nephrotic syndrome. Our patient presented with sepsis-like illness and acute kidney injury during the neonatal period. Subsequent urine analysis showed persistent heavy proteinuria with concomitant hypoalbuminaemia and clinical anasarca. Screening for congenital i...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Medical Journal of Malaysia
2022
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/43231/5/A%20stitch.pdf http://ir.unimas.my/id/eprint/43231/ http://mjmcasereports.org/?view=article&id=7:home&catid=10 |
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| Summary: | We report a case of congenital nephrotic syndrome. Our
patient presented with sepsis-like illness and acute kidney
injury during the neonatal period. Subsequent urine analysis
showed persistent heavy proteinuria with concomitant
hypoalbuminaemia and clinical anasarca. Screening for
congenital infections was negative. Diuresis was initially
induced with daily albumin infusion. Subsequently,
administration of furosemide combined with amiloride was
adopted as albumin-sparing strategies. Both angiotensin�converting enzyme inhibitor and non-steroidal anti�inflammatory drugs were started after 4 weeks of life. Such treatment strategies resulted in a significant reduction in the need for albumin infusion, thus allowing better preservation of the venous estate and improving quality of life with a reduced need for inpatient care. |
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