Isolation and structural modifications of ananixanthone from Calophyllum teysmannii and their cytotoxic activities
Two naturally occurring xanthones, ananixanthone (1) and β-mangostin (2), were isolated using column chromatographic method from the nhexane and methanol extracts of Calophyllum teysmannii, respectively. The major constituent, ananixanthone (1), was subjected to structural modifications via acety...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
Informa UK Limited
2017
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/38549/1/cytotoxic1.pdf http://ir.unimas.my/id/eprint/38549/ https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1367781?journalCode=gnpl20 https://doi.org/10.1080/14786419.2017.1367781 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Two naturally occurring xanthones, ananixanthone (1) and β-mangostin
(2), were isolated using column chromatographic method from the nhexane and methanol extracts of Calophyllum teysmannii, respectively.
The major constituent, ananixanthone (1), was subjected to structural
modifications via acetylation, methylation and benzylation yielding
four new xanthone derivatives, ananixanthone monoacetate (3),
ananixanthone diacetate (4), 5-methoxyananixanthone (5) and 5-Obenzylananixanthone (6). Compound 1 together with its four new
derivatives were subjected to MTT assay against three cancer cell lines;
SNU-1, K562 and LS174T. The results indicated that the parent compound
has greater cytotoxicity capabilities against SNU-1 and K562 cell lines
with IC50 values of 8.97 ± 0.11 and 2.96 ± 0.06 μg/mL, respectively.
Compound 5 on the other hand exhibited better cytotoxicity against
LS174T cell line with an IC50 value of 5.76 ± 1.07 μg/mL. |
|---|