One-pot and two-pot methods for chalcone derived pyrimidines synthesis and applications
Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
John Wiley & Sons, Inc
2021
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/34569/1/2021%20pyrimidine-review%201.pdf http://ir.unimas.my/id/eprint/34569/ https://onlinelibrary.wiley.com/doi/abs/10.1002/jhet.4226 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric,
and asymmetric pyrimidine via one-pot and two-pot methods. The one-pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two-pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries. |
|---|