Polymorphism in the Tumor Necrosis Factor alpha promoter region and its Influence on Colorectal Cancer Predispositiom risk in Malaysian Population

Polymorphism in the Tumor Necrosis Factor alpha promoter region and its Influence on Colorectal Cancer Predispositiom risk in Malaysian Population

Objective: A case control study was designed to investigate the TNF-,1 -308 G>A polymorphism allele frequencies and to determine the influence of the polymorphic gcnot.ype on sporadic CRC susceptibility risk in Malaysian population. Material. and Method!: Peripheral blood samples of 164 normal...

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Main Authors: Mohd Aminudin, Mustapha, Siti Nurfatimah, Mohd Shahpudin, Ahmad Aizat, Abdul Aziz, Murali Krishna, V Bhavaraju, Venkatesh, R. Naik, Zaidi, Zakaria, A. Shanwani, Mohd Sidek, Mohammad Radzi, Abu Hassan, Ravindran, Ankathil
Format: Article
Language:en
Published: Japan International Cultural Exchange Foundation (JICEF) 2011
Subjects:
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/30228/1/IMJ%20December%202011.pdf
http://ir.unimas.my/id/eprint/30228/
https://seronjihou.com/home/%e5%87%ba%e7%89%88%e7%89%a9/imj-international-medical-journal/
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Summary:Objective: A case control study was designed to investigate the TNF-,1 -308 G>A polymorphism allele frequencies and to determine the influence of the polymorphic gcnot.ype on sporadic CRC susceptibility risk in Malaysian population. Material. and Method!: Peripheral blood samples of 164 normal controls and 161 clinically and histopathologically con­firmed CRC patients were genotyped for TNF-u -308 G>A polymorphism employing allele specific PCR. The relative associa­tions of various genotypes with CRC susceptibility risk was determined by calculating Odds Ratios. Corresponding chi-square tests on the CRC patients and controls were carried out and 95% confidence interval (95% CI) were determined using Fisher e,acts tests. Results: On comparing the frequencies of genotypes of patients and controls, the homozygous ,·ariant AA was significantly higher in CRC patients (p = 0.030) compared to controls. On investigating the association of the polymorphic genotypes with CRC susceptibility risk, the homozygous variant TNF-a -308 AA showed significantly increased risk with OR 2.5842. Conclusion: Our results suggest that, pol) morphic genotJpe of inflammation response gene TNF-a is significantly associat­ed with CRC susceptibility risk and could be considered as a high risk variant for CRC predisposition.

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