Reversed phase thin layer chromatography of five co-administered drugs with surfactant modified solvent systems
The chromatography of five co-administered drugs i.e. paracetamol, ibuprofen, diclofenac sodium, aspirin and ascorbic acid was performed on various reversed phase layers. The surfactant mediated solvent systems were used with various impregnated silica gel H layers for the chromatography of these fi...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | en |
| Published: |
2009
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/29694/1/Reversed%20phase%20thin%20layer%20chromatography%20of%20five%20co-administered%20drugs%20with%20surfactant%20modified%20-%20Copy.pdf http://ir.unimas.my/id/eprint/29694/ http://nopr.niscair.res.in/handle/123456789/5916 |
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| Summary: | The chromatography of five co-administered drugs i.e. paracetamol, ibuprofen, diclofenac sodium, aspirin and ascorbic acid was performed on various reversed phase layers. The surfactant mediated solvent systems were used with various impregnated silica gel H layers for the chromatography of these five drugs. The various experimental conditions were optimized for the selection of optimum concentration of impregnants. The mutual separation of a mixture of paracetamol, diclofenac sodium and ibuprofen; and paracetamol, aspirin and ascorbic acid are achieved on various impregnated silica gel H layers, using surfactant mediated solvent systems containing n-hexane: 1% CTAB in MeOH: ethyl acetate: acetic acid, (13:1:4:2, v/v) and toluene: 1% CTAB in MeOH: n-propanol: formic acid, (14:1:3:2, v/v) respectively. |
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