Antimicrobial starch-citrate hydrogel for potential applications as drug delivery carriers
Antimicrobial starch-citrate hydrogels were prepared by physical crosslinking of starch citrate, Poly(vinyl alcohol (PVA) and Polyethylene glycol (PEG) via the freeze–thaw technique. This starch-citrate hydrogel exhibited excellent antimicrobial activity against various bacteria strains such as Esc...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Elsevier B.V.
2019
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/27448/1/Antimicrobial%20starch-citrate%20hydrogel%20for%20potential%20applications%20as%20drug%20%28abstract%29.pdf http://ir.unimas.my/id/eprint/27448/ https://www.sciencedirect.com/science/article/pii/S177322471930944X?via%3Dihub https://doi.org/10.1016/j.jddst.2019.101239 |
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| Summary: | Antimicrobial starch-citrate hydrogels were prepared by physical crosslinking of starch citrate, Poly(vinyl alcohol (PVA) and Polyethylene glycol (PEG) via the freeze–thaw technique. This starch-citrate hydrogel exhibited
excellent antimicrobial activity against various bacteria strains such as Escherichia coli (gram negative),
Staphylococcus pyogenes (gram negative), Salmonella thypimurium (gram positive) and Streptococcus aureus (gram
positive). Most notably it showed antimicrobial activity against the multiple antibiotic resistant (M.A.R) superbugs (Klebsiella pneumoniae). Penicillin G loaded starch-citrate hydrogel was observed to exhibit a sustain
release profile over 7 days. Penicillin G loaded starch-citrate hydrogel also exhibited synergistic antimicrobial
activities against Salmonella thypimurium, Escherichia coli (E-coli) (O15:H7) and E-coli control (ATC 2925). The
potential application of starch-citrate hydrogel as both antimicrobial agent and drug delivery carriers is therefore envisaged. |
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