The Association Between N-Terminal B-Type Natriuretic Peptide and One Year Clinical Outcome in Patients with Acute Myocardial Infarction : A Multicenter Study

Background: NT-proBNP is a useful biomarker in the management of heart failure. However, there is conflicting evidence for the prognostic value of NT-ProBNP in acute myocardial infarction (AMI). Objectives: (1) To explore the association between NT-proBNP and 1-year cardiac related mortality in A...

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Main Authors: Asri, Said, Koh, Keng Tat, Tan, S.S.N., Sim, P. P., Tiong, L.L., Ku, M. Y., Wong, I. T., Yong, K. Y., Lau, K. T., Chandan, D.B., Fong, S. L., Sia, T. L. L., Shu, F.E.P., Oon, Y.Y., Khaw, C.S., Ho, K. H., Tan, C.T., Khiew, Ning Zhan, Cham, Yee Ling, Voon, C.Y., Nor Hanim, Mohd Amin, Fong, A.Y.Y., Ong, T.K.
Format: Article
Language:en
Published: Elsevier 2018
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Online Access:http://ir.unimas.my/id/eprint/22940/1/N-Terminal%20B-Type%20Natriuretic%20Peptide.pdf
http://ir.unimas.my/id/eprint/22940/
https://www.journals.elsevier.com/international-journal-of-cardiology
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Summary:Background: NT-proBNP is a useful biomarker in the management of heart failure. However, there is conflicting evidence for the prognostic value of NT-ProBNP in acute myocardial infarction (AMI). Objectives: (1) To explore the association between NT-proBNP and 1-year cardiac related mortality in AMI patients. (2) To explore the association between NT-proBNP and 1-year risk of sudden cardiac death or ventricular arrhythmia, readmission for heart failure, readmission for acute coronary syndrome (ACS) and stroke. Methods: We conducted a multicenter, prospective observational study recruiting patients presenting with AMI between 1-August2016 to 31-January-2017, involving 1 cardiology referral center and 4 non-cardiology hospitals. NT-proBNP levels (Alere TriageĀ®, US) were measured within 24 hours of AMI diagnosis. Patients were followed-up for 1 year.