Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the pos...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Blackwell Publishing Inc.
2017
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/17878/ http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full |
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| Summary: | In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD. |
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