Increased serum levels of interleukin-6 and von Willenbrand Factor in early phase of acute coronary syndrome in a young and multiethnic Malaysian population
Objective Interleukin-6 (IL6; proinflammatory marker), von Willebrand Factor (vWF; endothelial dysfunction marker) and P-selectin ( platelet activation marker), may play important roles in defining the pathogenesis of vulnerable plaques in acute coronary syndrome (ACS). This study aims to inves...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
BMJ Publishing Group
2012
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/16907/1/Increased%20serum%20levels%20of%20interleukin%20-6%20%28abstract%29.pdf http://ir.unimas.my/id/eprint/16907/ https://www.researchgate.net/publication/236182448 |
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| Summary: | Objective Interleukin-6 (IL6; proinflammatory marker),
von Willebrand Factor (vWF; endothelial dysfunction
marker) and P-selectin ( platelet activation marker), may
play important roles in defining the pathogenesis of
vulnerable plaques in acute coronary syndrome (ACS).
This study aims to investigate the expression and
relationship of these markers in early phases of ACS in a
young and multiethnic Malaysian population.
Design Peripheral whole blood mRNA, and serum levels
of IL6, vWF and P-selectin were measured in 22 patients
with ACS, and in 28 controls with angiographically
significant coronary artery disease without previous ACS
events. Venous blood from ACS patients was obtained
within 1 h of hospital admission.
Results No significant differences of IL6, vWF and
P-selectin mRNA levels between ACS and controls were
seen. ACS patients had significantly higher serum levels
of IL6 and vWF ( p<0.001), compared with controls.
P-selectin correlated with IL6 (r=0.697, p=0.003) and
vWF (r=0.497, p=0.05) at mRNA levels, indicating a
possible association between these three indices of ACS
pathogenesis.
Conclusions Increased serum levels of IL6 and vWF
suggest that inflammation and endothelial dysfunction
may play a prominent role in the pathogenesis of the
disease during the early phase of ACS. |
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