Issues and Methodology for Development of Transgenic Fish for Aquaculture with a Focus on Growth Enhancement
The advent of gene transfer methods in model mammalian species in the early 1980s (Palmiter et al. 1982; Hammer et al. 1985a) provided impetus to genetically engineer a range of other vertebrates for applied purposes. In particular, the remarkable enhancement in growth rate of mice to transgene-d...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Blackwell Publishing
2025
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| Subjects: | |
| Online Access: | http://umt-ir.umt.edu.my:8080/handle/123456789/21764 |
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| Summary: | The advent of gene transfer methods in model mammalian species in the early 1980s
(Palmiter et al. 1982; Hammer et al. 1985a) provided impetus to genetically engineer
a range of other vertebrates for applied purposes. In particular, the remarkable enhancement
in growth rate of mice to transgene-derived overexpression of growth hormone
(GH) led to extensive transgenic studies in mammals for terrestrial agricultural
species (Pursel et al. 1989). For domesticated mammals, transgenesis resulted in only
modest growth acceleration (compared to effects in mice) and some improvements
in feed utilization, but were also associated with significant pleiotropic metabolic,
physiological, and morphological abnormalities (Pursel et al. 1989; Rexroad et al.
1989; Pursel et al. 1997; Rozycki et al. 1999; Pursel et al. 2004; Adams and Briegel
2005). Thus, this technology has not been applied in commercial agriculture, although
research to overcome some of these obstacles continues. |
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