Quorum sensing signals: Aquaculture risk factor
Bacteria produce several virulence factors and cause massive mortality in fish and crustaceans. Abundant quorum sensing (QS) signals and high cell density are essentially required for the production of such virulence factors. Although several strategies have been developed to control aquatic path...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
John wiley & Sons Australia, Ltd.
2025
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| Subjects: | |
| Online Access: | http://umt-ir.umt.edu.my:8080/handle/123456789/21747 |
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| Summary: | Bacteria produce several virulence factors and cause massive mortality in fish and
crustaceans. Abundant quorum sensing (QS) signals and high cell density are essentially
required for the production of such virulence factors. Although several strategies
have been developed to control aquatic pathogens through antibiotics and QS
inhibition, the impact of pre-existing QS signals in the aquatic environment has been
overlooked. QS signals cause detrimental effects on mammalian cells and induce cell
death by interfering with multiple cellular pathways. Moreover, QS signals not only
function as a messenger, but also annihilate the functions of the host immune system
which implies that QS signals should be designated as a major virulence factor.
Despite QS signals' role has been well documented in mammalian cells, their impact
on aquatic organisms is still at the budding stage. However, many aquatic organisms
produce enzymes that degrade and detoxify such QS signals. In addition, physical and
chemical factors also determine the stability of the QS signals in the aqueous environment.
The balance between QS signals and existing QS signals degrading factors
essentially determines the disease progression in aquatic organisms. In this review,
we highlight the impact of QS signals on aquatic organisms and further discussed
potential alternative strategies to control disease progression. |
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