Non-antibiotic approaches to combat motile Aeromonas infections in aquaculture: Current state of knowledge and future perspectives
Inland aquaculture contributed by three major fish groups, including carps, tilapias, and catfish plays a vital role in global food security and nutrition, particularly in low and middle-income countries. However, the sustainable development of this sector is hampered by disease epidemics, especi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
John Wiley & Sons Australia, Ltd
2025
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| Subjects: | |
| Online Access: | http://umt-ir.umt.edu.my:8080/handle/123456789/21729 |
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| Summary: | Inland aquaculture contributed by three major fish groups, including carps, tilapias,
and catfish plays a vital role in global food security and nutrition, particularly in low
and middle-income countries. However, the sustainable development of this sector is
hampered by disease epidemics, especially those caused by bacteria such as Aeromonas
species. At least eight pathogenic motile Aeromonas species (A. hydrophila,
A. veronii, A. jandaei, A. caviae, A. sobria, A. bestiarum, A. dhakensis and A. schubertii)
have been reported in aquaculture with some causing up to 100% mortality during
disease outbreaks. Simultaneously, emerging multidrug-resistant Aeromonas due to a
long-inappropriate use of antibiotics is alarming and highlights a global public health
concern and negative socioeconomic impacts. Here, we provide a comprehensive
overview of motile Aeromonas infections, antibiotic use and antimicrobial resistance
of Aeromonas species. This contribution also highlights the non-antibiotic approaches
(the solutions for preventing or treating of bacterial diseases without resorting to
antibiotic use) to control motile Aeromonas infections. In addition to the current state
of knowledge and limitations of each prophylaxis/therapy, perspectives for future
research are discussed critically, including oral/immersion multivalent vaccines, microencapsulated
synbiotics, exogenous metabolites, and novel lytic bacteriophage cocktails.
Some emerging applicable nanotechnology themes such as nanovaccines,
nanobioactive compounds, and nanobubbles are also included in this review. In summary, combating motile Aeromonas infections in aquaculture, including multidrugresistant
aeromonads, as well as other bacterial diseases, is a lengthy battle that
requires a strategic combination of multiple non-antibiotic approaches coherent with
the One Health philosophy. |
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