Protein–protein interaction network: an emerging tool for understanding fish disease in aquaculture
Protein–protein interactions (PPIs) play integral roles in a wide range of biological processes that regulate the overall growth, development, physiology and disease in living organisms. With the advancement of high-throughput sequencing technologies, increasing numbers of PPI networks are being...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en |
| Published: |
John Wiley & Sons Australia, Ltd
2025
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| Subjects: | |
| Online Access: | http://umt-ir.umt.edu.my:8080/handle/123456789/21692 |
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| Summary: | Protein–protein interactions (PPIs) play integral roles in a wide range of biological
processes that regulate the overall growth, development, physiology and disease
in living organisms. With the advancement of high-throughput sequencing
technologies, increasing numbers of PPI networks are being predicted and annotated,
and these contribute greatly towards the understanding of pathogenesis and
the discovery of novel drug targets for the treatment of diseases. The use of this
tool is gaining popularity in the identification, understanding and treatment of
diseases in humans and plants. Due to the importance of aquaculture in tackling
the global food crisis by producing cheap and high-quality protein source, the
maintenance of the overall health status of aquaculture species is essential. With
the increasing omics data on aquaculture species, the PPI network is an emerging
tool for fish health maintenance. In this review, we first introduce the concept of
PPI network, how they are discovered and their general application. Then, the
current status of aquaculture and disease in aquaculture are discussed. The different
applications of PPI network in aquaculture fish disease management such as
biomarker identification, mechanism prediction, understanding of host–pathogen
interaction, understanding of pathogen co-infection interaction, and potential
development of vaccines and treatments are subsequently highlighted. It is hoped
that this emerging tool – PPI network – would deepen our understanding of the
pathogenesis of various diseases and hasten the prevention and treatment processes
in aquaculture species. |
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