Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease
Alzheimer’s disease (AD) is a neurological disease caused by the accumulation of extracellular senile plaques consisting of β-amyloid peptide (Aβ) in the brain. A transgenic Caenorhabditis elegans which demonstrated paralysis due to the expression of human beta amyloid Aβ42 gene was used to study th...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
Researchgate
2020
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/44355/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/44355/ http://dx.doi.org/10.1101/2020.04.13.040105 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1836858532792631296 |
|---|---|
| author | Chee wah yuen Mardani Abdul Halim Vikneswaran murugaiyah Nazalan Najimudin Ghows Azzam |
| author_facet | Chee wah yuen Mardani Abdul Halim Vikneswaran murugaiyah Nazalan Najimudin Ghows Azzam |
| author_sort | Chee wah yuen |
| building | UMS Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaysia Sabah |
| content_source | UMS Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Alzheimer’s disease (AD) is a neurological disease caused by the accumulation of extracellular senile plaques consisting of β-amyloid peptide (Aβ) in the brain. A transgenic Caenorhabditis elegans which demonstrated paralysis due to the expression of human beta amyloid Aβ42 gene was used to study the anti-paralysis effect of mixed tocotrienols. The content of the mixed tocotrienols were 12.1% α-, 2.7% β-, 18.6% γ-, and 8.1% δ-tocotrienols. Mixed tocotrienols significantly delayed the Aβ-induced paralysis in the transgenic nematode and exhibited anti-oxidant properties towards Aβ-generated oxidative stress. The mixture also presented potent inhibitory activities against Aβ aggregation with an IC50 value of 600 ng/ml. It is concluded that mixed tocotrienols could potentially serve as a new therapeutic candidate for AD. |
| format | Article |
| id | my.ums.eprints-44355 |
| institution | Universiti Malaysia Sabah |
| language | en |
| publishDate | 2020 |
| publisher | Researchgate |
| record_format | eprints |
| spelling | my.ums.eprints-443552025-07-03T08:18:35Z https://eprints.ums.edu.my/id/eprint/44355/ Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease Chee wah yuen Mardani Abdul Halim Vikneswaran murugaiyah Nazalan Najimudin Ghows Azzam QP501-801 Animal biochemistry RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry Alzheimer’s disease (AD) is a neurological disease caused by the accumulation of extracellular senile plaques consisting of β-amyloid peptide (Aβ) in the brain. A transgenic Caenorhabditis elegans which demonstrated paralysis due to the expression of human beta amyloid Aβ42 gene was used to study the anti-paralysis effect of mixed tocotrienols. The content of the mixed tocotrienols were 12.1% α-, 2.7% β-, 18.6% γ-, and 8.1% δ-tocotrienols. Mixed tocotrienols significantly delayed the Aβ-induced paralysis in the transgenic nematode and exhibited anti-oxidant properties towards Aβ-generated oxidative stress. The mixture also presented potent inhibitory activities against Aβ aggregation with an IC50 value of 600 ng/ml. It is concluded that mixed tocotrienols could potentially serve as a new therapeutic candidate for AD. Researchgate 2020 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/44355/1/FULL%20TEXT.pdf Chee wah yuen and Mardani Abdul Halim and Vikneswaran murugaiyah and Nazalan Najimudin and Ghows Azzam (2020) Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease. pp. 1-15. http://dx.doi.org/10.1101/2020.04.13.040105 |
| spellingShingle | QP501-801 Animal biochemistry RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry Chee wah yuen Mardani Abdul Halim Vikneswaran murugaiyah Nazalan Najimudin Ghows Azzam Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease |
| title | Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease |
| title_full | Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease |
| title_fullStr | Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease |
| title_full_unstemmed | Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease |
| title_short | Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease |
| title_sort | tocotrienol decreases ß-amyloid mediated toxicity in caenorhabditis elegans model of alzheimer's disease |
| topic | QP501-801 Animal biochemistry RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry |
| url | https://eprints.ums.edu.my/id/eprint/44355/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/44355/ http://dx.doi.org/10.1101/2020.04.13.040105 |
| url_provider | http://eprints.ums.edu.my/ |