Microbial valorization of oil-based substrates for polyhydroxyalkanoates (PHA) production – Current strategies, status, and perspectives
With the rising interest in developing polyhydroxyalkanoate (PHA) bioplastics as an auspicious substitute for conventional plastics, the exploitation of low-cost oil substrates for PHA biosynthesis has become popular recently. In view of the paucity of feasibility studies on lipid-based PHA producti...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Elsevier
2023
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/44070/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/44070/ https://doi.org/10.1016/j.procbio.2023.05.013 |
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| Summary: | With the rising interest in developing polyhydroxyalkanoate (PHA) bioplastics as an auspicious substitute for conventional plastics, the exploitation of low-cost oil substrates for PHA biosynthesis has become popular recently. In view of the paucity of feasibility studies on lipid-based PHA production, this paper aims to provide an overview of the PHA production from diverse lipid-rich sources, covering the PHA production efficiencies using different plausible fermentation strategies and the key influencing factors for oil-based PHA production. Considering the high conversion efficiency (97.5% of the theoretical PHA yield), direct fermentation of oil has shown great promise for PHA industrialization. Plant oils which could achieve a high PHA yield (0.25–0.77 g/g) are better carbon sources than waste cooking oil (0.15–0.28 g/g). In addition to providing information on the potential enhancement tools (i.e., mixed cultures, metabolic engineering, and kinetic studies) for lipid-based PHA production, this paper also reviews the techno-economic and life cycle assessment of PHA production in comparison to the conventional plastics. Besides, technical challenges and future perspectives for the commercialization of oil-based PHA production have been discussed (specifically targeting on the concerns of inconsistent production efficiency, complex recovery process, and high production cost), offering further insights towards developing a sustainable circular economy. |
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