Risk factors,diagnosis, and management of peptic ulcer disease
For nearly 100 years, scientists and doctors thought that ulcers were caused by stress, spicy food, and alcohol. Treatment was bed rest and antacids, but in 1982 discovery of Helicobacter pylori confirmed its role in in gastric, duodenal ulcers and gastric cancer. Peptic ulcer disease (PUD) is the m...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
IQSR Journals
2015
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/42586/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/42586/ https://doi.org/10.9790/0853-14784046 |
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| Summary: | For nearly 100 years, scientists and doctors thought that ulcers were caused by stress, spicy food, and alcohol. Treatment was bed rest and antacids, but in 1982 discovery of Helicobacter pylori confirmed its role in in gastric, duodenal ulcers and gastric cancer. Peptic ulcer disease (PUD) is the most common human ailment affecting nearly 50% of world population, with high mortality in gastric cancer. Gastric ulcer had male preponderance; duodenal ulcer was 10 times as common as in women. The causes of PUD include H.pylori infection, non- steroidal anti- inflammatory drugs (NSAIDs), pepsin, smoking, alcohol, bile-acids, steroids, stress and changes in gastric mucin consistency. Other causes include Bechetdisease,Zollinger_Ellisonsyndrome,Crohndisease,livercirrhosis,stomach cancer, coronary heart disease and inflammation of stomach lining or gall bladder. Frequent symptoms include epigastric pain, nausea, flatulence, bloating and heartburn. The currently recommended eradication regimens should have eradication rate of 90% or greater. Triple therapy is consist of PPI,a combination of two antimicrobials such as amoxicillin and clarithromycin.Quardrupletherapy:PPI(sandard dose twice daily)+metronidazole(500 mg 3 times daily)+ tetracycline(500 mg 3 times daily)+bismuth(dose depend on preparation) for 10 days.Prognosis of PUD is excellent if the underlying cause such as H.pylori infection or use of NSAIDs can be addressed. |
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