Exploring novel pyridine carboxamide derivatives as urease inhibitors: synthesis, molecular docking, kinetic studies and ADME profile

The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity. A series of pyridine carboxamide and carbothioamide derivative...

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Main Authors:	Ayesha Naseer, Faisal Abdulrhman Osra, Asia Naz Awan, Aqeel Imran, Abdul Hameed, Syed Adnan Ali Shah, Jamshed Iqbal, Zainul Amiruddin Zakaria
Format:	Article
Language:	en
Published:	Multidisciplinary Digital Publishing Institute 2022
Subjects:	R5-920 Medicine (General) RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Online Access:	https://eprints.ums.edu.my/id/eprint/42524/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/42524/ https://doi.org/10.3390/ph15101288
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