Solubility of Rosmarinic Acid in Supercritical Carbon Dioxide Extraction from Orthosiphon stamineus Leaves
Rosmarinic acid (RA) is present in a broad variety of plants, including those in the Lamiaceae family, and has a wide range of pharmacological effects, particularly antioxidant activity. To extract RA from Orthosiphon stamineus (OS) leaves, a Lamiaceae plant, a suitable extraction process is necessa...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | en en |
| Published: |
MDPI
2022
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/34244/1/Solubility%20of%20Rosmarinic%20Acid%20in%20Supercritical%20Carbon%20Dioxide%20Extraction%20from%20Orthosiphon%20stamineus%20Leaves%20.pdf https://eprints.ums.edu.my/id/eprint/34244/2/Solubility%20of%20Rosmarinic%20Acid%20in%20Supercritical%20Carbon%20Dioxide%20Extraction%20from%20Orthosiphon%20stamineus%20Leaves%201.pdf https://eprints.ums.edu.my/id/eprint/34244/ https://www.mdpi.com/2305-7084/6/4/59 https://doi.org/10.3390/chemengineering6040059 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Rosmarinic acid (RA) is present in a broad variety of plants, including those in the Lamiaceae family, and has a wide range of pharmacological effects, particularly antioxidant activity. To extract RA from Orthosiphon stamineus (OS) leaves, a Lamiaceae plant, a suitable extraction process is necessary. The present study used a green extraction method of supercritical carbon dioxide (SCCO2) extraction with the addition of ethanol as a modifier to objectively measure and correlate the solubility of RA from OS leaves. The solubility of RA in SCCO2 was determined using a dynamic extraction approach, and the solubility data were correlated using three density-based semi-empirical models developed by Chrastil, del Valle-Aguilera, and Gonzalez. Temperatures of 40, 60, and 80 ◦C and pressures of 10, 20, and 30 MPa were used in the experiments. The maximum RA solubility was found at 80 ◦C and 10 MPa with 2.004 mg of rosmarinic acid/L solvent. The RA solubility data correlated strongly with the three semi-empirical models with less than 10% AARD. Furthermore, the fastest RA extraction rate of 0.0061 mg/g min−1 was recorded at 80 ◦C and 10 MPa, and the correlation using the Patricelli model was in strong agreement with experimental results with less than 15% AARD. |
|---|