Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers
Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases worldwide and are highly characterised by poor prognosis. The poor overall survival is mainly due to late detection and emerging challenges in treatment, particularly chemoresistance. Thus, the identification of no...
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Bentham Science Publishers
2021
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| Online Access: | https://eprints.ums.edu.my/id/eprint/33558/1/Molecular%20regulatory%20roles%20of%20long%20non-coding%20RNA%20HOTTIP%2C%20An%20overview%20in%20gastrointestinal%20cancers.ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/33558/3/Molecular%20regulatory%20roles%20of%20long%20non-coding%20RNA%20HOTTIP.pdf https://eprints.ums.edu.my/id/eprint/33558/ https://www.eurekaselect.com/article/117162 https://doi.org/10.2174/1566524021666210806162848 |
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| author | Ummi Zulaiqha Hamid Maw Shin Sim Rhanye Mac Guad Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Choy Ker Woon Ismail Muhamad Fareez Srinivasa Reddy Bonam Yuan Seng Wu |
| author_facet | Ummi Zulaiqha Hamid Maw Shin Sim Rhanye Mac Guad Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Choy Ker Woon Ismail Muhamad Fareez Srinivasa Reddy Bonam Yuan Seng Wu |
| author_sort | Ummi Zulaiqha Hamid |
| building | UMS Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaysia Sabah |
| content_source | UMS Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases worldwide and are highly characterised by poor prognosis. The poor overall survival is mainly due to late detection and emerging challenges in treatment, particularly chemoresistance. Thus, the identification of novel molecular targets in GI cancer is highly regarded as the main focus. Recently, long non-coding RNAs (lncRNAs) have been discovered as potential novel molecular targets for combating cancer, as they are highly associated with carcinogenesis and have a great impact on cancer progression. Amongst lncRNAs, HOTTIP has demonstrated a prominent oncogenic regulation in cancer progression, particularly in GI cancers, including oesophageal cancer, gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. This review aimed to present a focused update on the regulatory roles of HOTTIP in GI cancer progression and chemoresistance, as well as deciphering the associated molecular mechanisms underlying their impact on cancer phenotypes and chemoresistance and the key molecules involved. It has been reported that it regulates the expression of various genes and proteins in GI cancers that impact cellular functions, including proliferation, adhesion, migration and invasion, apoptosis, chemosensitivity, and tumour differentiation. Furthermore, HOTTIP was also discovered to have a higher diagnostic value as compared to existing diagnostic biomarkers. Overall, HOTTIP has presented itself as a novel therapeutic target and potential diagnostic biomarker in the development of GI cancer treatment. |
| format | Article |
| id | my.ums.eprints-33558 |
| institution | Universiti Malaysia Sabah |
| language | en en |
| publishDate | 2021 |
| publisher | Bentham Science Publishers |
| record_format | eprints |
| spelling | my.ums.eprints-335582022-09-02T15:01:22Z https://eprints.ums.edu.my/id/eprint/33558/ Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers Ummi Zulaiqha Hamid Maw Shin Sim Rhanye Mac Guad Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Choy Ker Woon Ismail Muhamad Fareez Srinivasa Reddy Bonam Yuan Seng Wu RC799-869 Diseases of the digestive system. Gastroenterology Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases worldwide and are highly characterised by poor prognosis. The poor overall survival is mainly due to late detection and emerging challenges in treatment, particularly chemoresistance. Thus, the identification of novel molecular targets in GI cancer is highly regarded as the main focus. Recently, long non-coding RNAs (lncRNAs) have been discovered as potential novel molecular targets for combating cancer, as they are highly associated with carcinogenesis and have a great impact on cancer progression. Amongst lncRNAs, HOTTIP has demonstrated a prominent oncogenic regulation in cancer progression, particularly in GI cancers, including oesophageal cancer, gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. This review aimed to present a focused update on the regulatory roles of HOTTIP in GI cancer progression and chemoresistance, as well as deciphering the associated molecular mechanisms underlying their impact on cancer phenotypes and chemoresistance and the key molecules involved. It has been reported that it regulates the expression of various genes and proteins in GI cancers that impact cellular functions, including proliferation, adhesion, migration and invasion, apoptosis, chemosensitivity, and tumour differentiation. Furthermore, HOTTIP was also discovered to have a higher diagnostic value as compared to existing diagnostic biomarkers. Overall, HOTTIP has presented itself as a novel therapeutic target and potential diagnostic biomarker in the development of GI cancer treatment. Bentham Science Publishers 2021-08-06 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/33558/1/Molecular%20regulatory%20roles%20of%20long%20non-coding%20RNA%20HOTTIP%2C%20An%20overview%20in%20gastrointestinal%20cancers.ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/33558/3/Molecular%20regulatory%20roles%20of%20long%20non-coding%20RNA%20HOTTIP.pdf Ummi Zulaiqha Hamid and Maw Shin Sim and Rhanye Mac Guad and Vetriselvan Subramaniyan and Mahendran Sekar and Neeraj Kumar Fuloria and Shivkanya Fuloria and Choy Ker Woon and Ismail Muhamad Fareez and Srinivasa Reddy Bonam and Yuan Seng Wu (2021) Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers. Current Molecular Medicine, 22. pp. 478-490. ISSN 1566-5240 (P-ISSN) , 1875-5666 (E-ISSN) https://www.eurekaselect.com/article/117162 https://doi.org/10.2174/1566524021666210806162848 https://doi.org/10.2174/1566524021666210806162848 |
| spellingShingle | RC799-869 Diseases of the digestive system. Gastroenterology Ummi Zulaiqha Hamid Maw Shin Sim Rhanye Mac Guad Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Choy Ker Woon Ismail Muhamad Fareez Srinivasa Reddy Bonam Yuan Seng Wu Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers |
| title | Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers |
| title_full | Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers |
| title_fullStr | Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers |
| title_full_unstemmed | Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers |
| title_short | Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers |
| title_sort | molecular regulatory roles of long non-coding rna hottip: an overview in gastrointestinal cancers |
| topic | RC799-869 Diseases of the digestive system. Gastroenterology |
| url | https://eprints.ums.edu.my/id/eprint/33558/1/Molecular%20regulatory%20roles%20of%20long%20non-coding%20RNA%20HOTTIP%2C%20An%20overview%20in%20gastrointestinal%20cancers.ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/33558/3/Molecular%20regulatory%20roles%20of%20long%20non-coding%20RNA%20HOTTIP.pdf https://eprints.ums.edu.my/id/eprint/33558/ https://www.eurekaselect.com/article/117162 https://doi.org/10.2174/1566524021666210806162848 https://doi.org/10.2174/1566524021666210806162848 |
| url_provider | http://eprints.ums.edu.my/ |