Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms
Medicinal plants with less side effects are paramount important for humankind to cure various ailments as compared to newly developed allopathic medicines. Synsepalum dulcificum Daniell (Sapotaceae), is well known as miracle fruits due to its distinctive taste-modifying property. This review aimed t...
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Universiti Kebangsaan Malaysia
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/32802/1/Deciphering%20Synsepalum%20dulcificum%20as%20an%20Arising%20Phytotherapy%20Agent.pdf https://eprints.ums.edu.my/id/eprint/32802/2/Deciphering%20Synsepalum%20dulcificum%20as%20an%20Arising%20Phytotherapy%20Agent1.pdf https://eprints.ums.edu.my/id/eprint/32802/ https://www.ukm.my/jsm/pdf_files/SM-PDF-51-1-2022/16.pdf http://doi.org/10.17576/jsm-2022-5101-16 |
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| author | Jia, Wer Ee Appalaraju Velaga Rhanye Mac Guad Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Ker, Woon Choy Yuan, Seng Wu |
| author_facet | Jia, Wer Ee Appalaraju Velaga Rhanye Mac Guad Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Ker, Woon Choy Yuan, Seng Wu |
| author_sort | Jia, Wer Ee |
| building | UMS Library |
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| content_provider | Universiti Malaysia Sabah |
| content_source | UMS Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Medicinal plants with less side effects are paramount important for humankind to cure various ailments as compared to newly developed allopathic medicines. Synsepalum dulcificum Daniell (Sapotaceae), is well known as miracle fruits due to its distinctive taste-modifying property. This review aimed to discuss its recent reported pharmacological properties and associated molecular mechanisms as a novel phytotherapy agent. In addition, background, phytochemical analysis and toxicological studies were also discussed as the foundation and added values for this review. It was discovered that S. dulcificum is endowed with various classes of phytochemicals, such as flavonoids, tannins, alkaloids and saponins. This review ravelled that S. dulcificum is a potent medicinal plant associated with antioxidant, antidiabetic, antimicrobial, anticancer, anti-hyperuricemic, hepatoprotective, anti-hyperlipidaemic, and anticonvulsant activities, with less toxicity shown. Future research may explore further the corresponding phytochemicals, associated molecular mechanisms, toxicological and pharmacokinetic profile before subjecting to clinical testing. |
| format | Article |
| id | my.ums.eprints-32802 |
| institution | Universiti Malaysia Sabah |
| language | en en |
| publishDate | 2022 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my.ums.eprints-328022022-06-16T07:01:36Z https://eprints.ums.edu.my/id/eprint/32802/ Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms Jia, Wer Ee Appalaraju Velaga Rhanye Mac Guad Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Ker, Woon Choy Yuan, Seng Wu RM1-950 Therapeutics. Pharmacology RV1-431 Botanic, Thomsonian, and eclectic medicine Medicinal plants with less side effects are paramount important for humankind to cure various ailments as compared to newly developed allopathic medicines. Synsepalum dulcificum Daniell (Sapotaceae), is well known as miracle fruits due to its distinctive taste-modifying property. This review aimed to discuss its recent reported pharmacological properties and associated molecular mechanisms as a novel phytotherapy agent. In addition, background, phytochemical analysis and toxicological studies were also discussed as the foundation and added values for this review. It was discovered that S. dulcificum is endowed with various classes of phytochemicals, such as flavonoids, tannins, alkaloids and saponins. This review ravelled that S. dulcificum is a potent medicinal plant associated with antioxidant, antidiabetic, antimicrobial, anticancer, anti-hyperuricemic, hepatoprotective, anti-hyperlipidaemic, and anticonvulsant activities, with less toxicity shown. Future research may explore further the corresponding phytochemicals, associated molecular mechanisms, toxicological and pharmacokinetic profile before subjecting to clinical testing. Universiti Kebangsaan Malaysia 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32802/1/Deciphering%20Synsepalum%20dulcificum%20as%20an%20Arising%20Phytotherapy%20Agent.pdf text en https://eprints.ums.edu.my/id/eprint/32802/2/Deciphering%20Synsepalum%20dulcificum%20as%20an%20Arising%20Phytotherapy%20Agent1.pdf Jia, Wer Ee and Appalaraju Velaga and Rhanye Mac Guad and Vetriselvan Subramaniyan and Neeraj Kumar Fuloria and Shivkanya Fuloria and Ker, Woon Choy and Yuan, Seng Wu (2022) Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms. Sains Malaysiana, 51. pp. 199-208. ISSN 0126-6039 https://www.ukm.my/jsm/pdf_files/SM-PDF-51-1-2022/16.pdf http://doi.org/10.17576/jsm-2022-5101-16 http://doi.org/10.17576/jsm-2022-5101-16 |
| spellingShingle | RM1-950 Therapeutics. Pharmacology RV1-431 Botanic, Thomsonian, and eclectic medicine Jia, Wer Ee Appalaraju Velaga Rhanye Mac Guad Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Ker, Woon Choy Yuan, Seng Wu Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms |
| title | Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms |
| title_full | Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms |
| title_fullStr | Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms |
| title_full_unstemmed | Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms |
| title_short | Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms |
| title_sort | deciphering synsepalum dulcificum as an arising phytotherapy agent: background, phytochemical and pharmacological properties with associated molecular mechanisms |
| topic | RM1-950 Therapeutics. Pharmacology RV1-431 Botanic, Thomsonian, and eclectic medicine |
| url | https://eprints.ums.edu.my/id/eprint/32802/1/Deciphering%20Synsepalum%20dulcificum%20as%20an%20Arising%20Phytotherapy%20Agent.pdf https://eprints.ums.edu.my/id/eprint/32802/2/Deciphering%20Synsepalum%20dulcificum%20as%20an%20Arising%20Phytotherapy%20Agent1.pdf https://eprints.ums.edu.my/id/eprint/32802/ https://www.ukm.my/jsm/pdf_files/SM-PDF-51-1-2022/16.pdf http://doi.org/10.17576/jsm-2022-5101-16 http://doi.org/10.17576/jsm-2022-5101-16 |
| url_provider | http://eprints.ums.edu.my/ |