Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region
Background: Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a new entity described in the 2016 World Health Organization (WHO) classification of brain tumors. While DL-GNT is predominantly an indolent tumor that affects young boys, high-grade DL-GNT is unusual and seldom reported in children.C...
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| Format: | Experiment |
| Language: | en en |
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2021
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| Online Access: | https://eprints.ums.edu.my/id/eprint/32221/1/Unusual%20High-Grade%20Diffuse%20Leptomeningeal%20Glioneuronal%20Tumor%20Mimicking%20Tuberculous%20Meningitis%20in%20a%20Child%20from%20an%20Endemic%20Region.pdf https://eprints.ums.edu.my/id/eprint/32221/2/Unusual%20High-Grade%20Diffuse%20Leptomeningeal%20Glioneuronal%20Tumor%20Mimicking%20Tuberculous%20Meningitis%20in%20a%20Child%20from%20an%20Endemic%20Region1.pdf https://eprints.ums.edu.my/id/eprint/32221/ https://www.frontiersin.org/articles/10.3389/fped.2021.767614/full |
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| author | Yong Guang Teh Nornazirah Azizan Nur Atifah Mohd Naim Chiak, Yot Ng Ke, Juin Wong Faizah Mohd Zaki |
| author_facet | Yong Guang Teh Nornazirah Azizan Nur Atifah Mohd Naim Chiak, Yot Ng Ke, Juin Wong Faizah Mohd Zaki |
| author_sort | Yong Guang Teh |
| building | UMS Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaysia Sabah |
| content_source | UMS Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Background: Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a new entity described in the 2016 World Health Organization (WHO) classification of brain tumors. While DL-GNT is predominantly an indolent tumor that affects young boys, high-grade DL-GNT is unusual and seldom reported in children.Case Presentation: In this report, we describe the challenges and pitfalls associated with diagnosing this high-grade variant in a tuberculosis-endemic region. We highlight the importance of identifying non-typical imaging findings, i.e., non-enhancing cystic lesions with high T2 signal along the leptomeningeal surface, that may expedite the diagnosis of this condition. Histopathologic correlations with MR spectroscopy findings are also discussed. Conclusion: We provide the first clinical imaging report of utilizing MR spectroscopy to distinguish DL-GNT from tuberculosis with histopathologic correlation. |
| format | Experiment |
| id | my.ums.eprints-32221 |
| institution | Universiti Malaysia Sabah |
| language | en en |
| publishDate | 2021 |
| record_format | eprints |
| spelling | my.ums.eprints-322212022-04-01T06:52:36Z https://eprints.ums.edu.my/id/eprint/32221/ Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region Yong Guang Teh Nornazirah Azizan Nur Atifah Mohd Naim Chiak, Yot Ng Ke, Juin Wong Faizah Mohd Zaki RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RJ1-570 Pediatrics Background: Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a new entity described in the 2016 World Health Organization (WHO) classification of brain tumors. While DL-GNT is predominantly an indolent tumor that affects young boys, high-grade DL-GNT is unusual and seldom reported in children.Case Presentation: In this report, we describe the challenges and pitfalls associated with diagnosing this high-grade variant in a tuberculosis-endemic region. We highlight the importance of identifying non-typical imaging findings, i.e., non-enhancing cystic lesions with high T2 signal along the leptomeningeal surface, that may expedite the diagnosis of this condition. Histopathologic correlations with MR spectroscopy findings are also discussed. Conclusion: We provide the first clinical imaging report of utilizing MR spectroscopy to distinguish DL-GNT from tuberculosis with histopathologic correlation. 2021 Experiment NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/32221/1/Unusual%20High-Grade%20Diffuse%20Leptomeningeal%20Glioneuronal%20Tumor%20Mimicking%20Tuberculous%20Meningitis%20in%20a%20Child%20from%20an%20Endemic%20Region.pdf text en https://eprints.ums.edu.my/id/eprint/32221/2/Unusual%20High-Grade%20Diffuse%20Leptomeningeal%20Glioneuronal%20Tumor%20Mimicking%20Tuberculous%20Meningitis%20in%20a%20Child%20from%20an%20Endemic%20Region1.pdf Yong Guang Teh and Nornazirah Azizan and Nur Atifah Mohd Naim and Chiak, Yot Ng and Ke, Juin Wong and Faizah Mohd Zaki (2021) Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region. [Experiment] https://www.frontiersin.org/articles/10.3389/fped.2021.767614/full |
| spellingShingle | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RJ1-570 Pediatrics Yong Guang Teh Nornazirah Azizan Nur Atifah Mohd Naim Chiak, Yot Ng Ke, Juin Wong Faizah Mohd Zaki Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region |
| title | Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region |
| title_full | Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region |
| title_fullStr | Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region |
| title_full_unstemmed | Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region |
| title_short | Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child from an Endemic Region |
| title_sort | case report: unusual high-grade diffuse leptomeningeal glioneuronal tumor mimicking tuberculous meningitis in a child from an endemic region |
| topic | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RJ1-570 Pediatrics |
| url | https://eprints.ums.edu.my/id/eprint/32221/1/Unusual%20High-Grade%20Diffuse%20Leptomeningeal%20Glioneuronal%20Tumor%20Mimicking%20Tuberculous%20Meningitis%20in%20a%20Child%20from%20an%20Endemic%20Region.pdf https://eprints.ums.edu.my/id/eprint/32221/2/Unusual%20High-Grade%20Diffuse%20Leptomeningeal%20Glioneuronal%20Tumor%20Mimicking%20Tuberculous%20Meningitis%20in%20a%20Child%20from%20an%20Endemic%20Region1.pdf https://eprints.ums.edu.my/id/eprint/32221/ https://www.frontiersin.org/articles/10.3389/fped.2021.767614/full |
| url_provider | http://eprints.ums.edu.my/ |