Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells
Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomat...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en en |
| Published: |
Multidisciplinary Digital Publishing Institute (MDPI)
2021
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/31529/1/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells.pdf https://eprints.ums.edu.my/id/eprint/31529/2/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells1.pdf https://eprints.ums.edu.my/id/eprint/31529/ https://www.mdpi.com/2073-4360/13/19/3290/htm https://doi.org/10.3390/polym13193290 |
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| Summary: | Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomaterial for culturing human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). The characterization of the peptide/m-GO films was performed, and the biocompatibility of the WJ-MSCs on the peptide/m-GO films was investigated. The results demonstrated that the peptide conjugate on the m-GO film did not hamper the normal growth of WJ-MSCs but supported the growth of WJ-MSCs after the 6-day culture period. In addition, the osteogenic differentiation of WJMSCs on the peptide/m-GO films was enhanced as compared with the parent m-GO film. Therefore, such peptide-conjugated m-GO films could provide a highly biocompatible and multifunctional 2D material to tailor the potential application of WJ-MSCs in bone tissue regeneration. |
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