Paraneoplastic optic neuropathy secondary to adenocarcinoma of the lung

We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand moveme...

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Bibliographic Details
Main Authors: Yap, Jin Yi, Wan-Hazabbah Wan HItam, Sanihah Abdul Halim, Nurul Ain Masnon
Format: Article
Language:en
en
Published: BMJ Publishing Group 2021
Subjects:
Online Access:https://eprints.ums.edu.my/id/eprint/30323/1/Paraneoplastic%20optic%20neuropathy%20secondary%20to%20adenocarcinoma%20of%20the%20lung%20ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/30323/2/Paraneoplastic%20optic%20neuropathy%20secondary%20to%20adenocarcinoma%20of%20the%20lung%20FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/30323/
https://casereports.bmj.com/content/bmjcr/14/5/e242082.full.pdf?casa_token=hdEolODRxeYAAAAA:1h4yeLwb7LsLI0EHa1Zl21yWC4s1CbKDF4V8ttF0CXIf3cUKl3aWzZTB1LNVoGTbJc6h1YYrPoY3_Q
http://dx.doi.org/10.1136/bcr-2021-242082
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Summary:We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. There was a generalised restriction of extraocular muscle movements in both eyes. Funduscopy showed a bilateral pale optic disc. A paraneoplastic antigen autoimmune profile showed a positive anti-CV2/CRMP-5 antibody. CT of the thorax revealed the presence of right apical lung mass, confirmed to be adenocarcinoma through a biopsy. She was scheduled for lung lobectomy and chemotherapy. Unfortunately, her health deteriorated and she passed away eventually.