Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae)
Murraya koenigii (L.) Spreng. (Rutaceae), a common spice, has been traditionally used to reduce inflammation and hepatitis. The present study aimed to reveal the antioxidant and anti-inflammatory activity as well as the regulation of cytochrome P450 levels elicited by aqueous extracts of M. koenigii...
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Royal Society of Chemistry
2015
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| Online Access: | https://eprints.ums.edu.my/id/eprint/29089/1/Antioxidant%20and%20hepatoprotective%20effects%20of%20the%20food%20seasoning%20curry%20leaves%20Murraya%20koenigii%20ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/29089/2/Antioxidant%20and%20hepatoprotective%20effects%20of%20the%20food%20seasoning%20curry%20leaves%20Murraya%20koenigii%20%28L.%29%20Spreng.%20%28Rutaceae%29.pdf https://eprints.ums.edu.my/id/eprint/29089/ https://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra19154h https://doi.org/10.1039/c5ra19154h |
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| author | Wan, Yong Ho Boon, Kee Beh Kian, Lam Lim Nurul Elyani Mohamad Hamidah Mohd Yusof Huynh Ky Sheau, Wei Tan Anisah Jamaluddin Kamariah Long Chung, Lu Lim Noorjahan Banu Alitheen Swee, Keong Yeap |
| author_facet | Wan, Yong Ho Boon, Kee Beh Kian, Lam Lim Nurul Elyani Mohamad Hamidah Mohd Yusof Huynh Ky Sheau, Wei Tan Anisah Jamaluddin Kamariah Long Chung, Lu Lim Noorjahan Banu Alitheen Swee, Keong Yeap |
| author_sort | Wan, Yong Ho |
| building | UMS Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaysia Sabah |
| content_source | UMS Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Murraya koenigii (L.) Spreng. (Rutaceae), a common spice, has been traditionally used to reduce inflammation and hepatitis. The present study aimed to reveal the antioxidant and anti-inflammatory activity as well as the regulation of cytochrome P450 levels elicited by aqueous extracts of M. koenigii leaves in response to paracetamol-induced liver toxicity in BALB/c mice. Liver toxicity was induced by an overdose of paracetamol followed by treatment with a M. koenigii leaf aqueous extract. The levels of serum liver markers, liver antioxidants, inflammatory markers and liver cytochrome P450 2E1 were quantified after 14 days of treatment. Histopathological analysis of the liver was also carried out. In vitro antioxidant levels and phenolic acid characterization were also performed. The extracts (50 and 200 mg kg-1 body weight) effectively restored the serum liver profiles (alanine transaminase, aspartate transaminase and alkaline phosphatase), liver antioxidant levels (superoxide dismutase, glutathione and ferric reducing ability of plasma) and inflammatory markers (tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor kappa-light-chain-enhancer of activated B cells and nitric oxide) to healthy levels in a dosage dependent manner. The level of liver cytochrome P450 2E1 was also lowered in the extract treated groups. Histopathological assessment showed that treatment with 200 mg kg-1 of the M. koenigii aqueous extract was able to reduce liver necrosis in mice fed paracetamol. Gallic acid concentration was the highest among all the phenolic acids detected in the extract. These results suggested that the M. koenigii aqueous extract, which possessed antioxidant and anti-inflammatory effects, can be used as a potential treatment for liver diseases caused by oxidative stress. |
| format | Article |
| id | my.ums.eprints-29089 |
| institution | Universiti Malaysia Sabah |
| language | en en |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| record_format | eprints |
| spelling | my.ums.eprints-290892021-09-27T05:34:44Z https://eprints.ums.edu.my/id/eprint/29089/ Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae) Wan, Yong Ho Boon, Kee Beh Kian, Lam Lim Nurul Elyani Mohamad Hamidah Mohd Yusof Huynh Ky Sheau, Wei Tan Anisah Jamaluddin Kamariah Long Chung, Lu Lim Noorjahan Banu Alitheen Swee, Keong Yeap RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Murraya koenigii (L.) Spreng. (Rutaceae), a common spice, has been traditionally used to reduce inflammation and hepatitis. The present study aimed to reveal the antioxidant and anti-inflammatory activity as well as the regulation of cytochrome P450 levels elicited by aqueous extracts of M. koenigii leaves in response to paracetamol-induced liver toxicity in BALB/c mice. Liver toxicity was induced by an overdose of paracetamol followed by treatment with a M. koenigii leaf aqueous extract. The levels of serum liver markers, liver antioxidants, inflammatory markers and liver cytochrome P450 2E1 were quantified after 14 days of treatment. Histopathological analysis of the liver was also carried out. In vitro antioxidant levels and phenolic acid characterization were also performed. The extracts (50 and 200 mg kg-1 body weight) effectively restored the serum liver profiles (alanine transaminase, aspartate transaminase and alkaline phosphatase), liver antioxidant levels (superoxide dismutase, glutathione and ferric reducing ability of plasma) and inflammatory markers (tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor kappa-light-chain-enhancer of activated B cells and nitric oxide) to healthy levels in a dosage dependent manner. The level of liver cytochrome P450 2E1 was also lowered in the extract treated groups. Histopathological assessment showed that treatment with 200 mg kg-1 of the M. koenigii aqueous extract was able to reduce liver necrosis in mice fed paracetamol. Gallic acid concentration was the highest among all the phenolic acids detected in the extract. These results suggested that the M. koenigii aqueous extract, which possessed antioxidant and anti-inflammatory effects, can be used as a potential treatment for liver diseases caused by oxidative stress. Royal Society of Chemistry 2015 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/29089/1/Antioxidant%20and%20hepatoprotective%20effects%20of%20the%20food%20seasoning%20curry%20leaves%20Murraya%20koenigii%20ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/29089/2/Antioxidant%20and%20hepatoprotective%20effects%20of%20the%20food%20seasoning%20curry%20leaves%20Murraya%20koenigii%20%28L.%29%20Spreng.%20%28Rutaceae%29.pdf Wan, Yong Ho and Boon, Kee Beh and Kian, Lam Lim and Nurul Elyani Mohamad and Hamidah Mohd Yusof and Huynh Ky and Sheau, Wei Tan and Anisah Jamaluddin and Kamariah Long and Chung, Lu Lim and Noorjahan Banu Alitheen and Swee, Keong Yeap (2015) Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae). RSC Advances, 5. pp. 100589-100597. ISSN 2046-2069 https://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra19154h https://doi.org/10.1039/c5ra19154h https://doi.org/10.1039/c5ra19154h |
| spellingShingle | RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Wan, Yong Ho Boon, Kee Beh Kian, Lam Lim Nurul Elyani Mohamad Hamidah Mohd Yusof Huynh Ky Sheau, Wei Tan Anisah Jamaluddin Kamariah Long Chung, Lu Lim Noorjahan Banu Alitheen Swee, Keong Yeap Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae) |
| title | Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae) |
| title_full | Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae) |
| title_fullStr | Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae) |
| title_full_unstemmed | Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae) |
| title_short | Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae) |
| title_sort | antioxidant and hepatoprotective effects of the food seasoning curry leaves murraya koenigii (l.) spreng. (rutaceae) |
| topic | RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) |
| url | https://eprints.ums.edu.my/id/eprint/29089/1/Antioxidant%20and%20hepatoprotective%20effects%20of%20the%20food%20seasoning%20curry%20leaves%20Murraya%20koenigii%20ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/29089/2/Antioxidant%20and%20hepatoprotective%20effects%20of%20the%20food%20seasoning%20curry%20leaves%20Murraya%20koenigii%20%28L.%29%20Spreng.%20%28Rutaceae%29.pdf https://eprints.ums.edu.my/id/eprint/29089/ https://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra19154h https://doi.org/10.1039/c5ra19154h https://doi.org/10.1039/c5ra19154h |
| url_provider | http://eprints.ums.edu.my/ |