Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo
North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB...
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Oxford University Press on behalf of the Society for Molecular Biology and Evolution
2020
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| Online Access: | https://eprints.ums.edu.my/id/eprint/27521/1/Shared%20Signature%20of%20Recent%20Positive%20Selection%20on%20the%20abstract.pdf https://eprints.ums.edu.my/id/eprint/27521/2/Shared%20signature%20of%20recent%20positive%20selection%20on%20the%20TSBP1-BTNL2-HLA-DRA%20genes%20in%20five%20native%20populations%20from%20North%20Borneo%20Fulltext.pdf https://eprints.ums.edu.my/id/eprint/27521/ https://doi.org/10.1093/gbe/evaa207 https://doi.org/:10.1093/gbe/evaa207 |
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| author | Hoh, Boon Peng Xiaoxi Zhang Lian Deng Kai Yuan Yew, Chee Wei Saw, Woei Yuh Mohammad Zahirul Hoque Farhang Aghakhanian Maude E. Phipps Vijay Kumar Subbiah Xu, Shu hua |
| author_facet | Hoh, Boon Peng Xiaoxi Zhang Lian Deng Kai Yuan Yew, Chee Wei Saw, Woei Yuh Mohammad Zahirul Hoque Farhang Aghakhanian Maude E. Phipps Vijay Kumar Subbiah Xu, Shu hua |
| author_sort | Hoh, Boon Peng |
| building | UMS Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaysia Sabah |
| content_source | UMS Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of 2.2 million genome-wide single nucleotide polymorphisms. As a result, an 13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1–BTNL2–HLA-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB population sandis estimated to have arisen5.5thousand years(220generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment. |
| format | Article |
| id | my.ums.eprints-27521 |
| institution | Universiti Malaysia Sabah |
| language | en en |
| publishDate | 2020 |
| publisher | Oxford University Press on behalf of the Society for Molecular Biology and Evolution |
| record_format | eprints |
| spelling | my.ums.eprints-275212021-07-01T14:18:37Z https://eprints.ums.edu.my/id/eprint/27521/ Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo Hoh, Boon Peng Xiaoxi Zhang Lian Deng Kai Yuan Yew, Chee Wei Saw, Woei Yuh Mohammad Zahirul Hoque Farhang Aghakhanian Maude E. Phipps Vijay Kumar Subbiah Xu, Shu hua R Medicine (General) North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of 2.2 million genome-wide single nucleotide polymorphisms. As a result, an 13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1–BTNL2–HLA-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB population sandis estimated to have arisen5.5thousand years(220generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment. Oxford University Press on behalf of the Society for Molecular Biology and Evolution 2020 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/27521/1/Shared%20Signature%20of%20Recent%20Positive%20Selection%20on%20the%20abstract.pdf text en https://eprints.ums.edu.my/id/eprint/27521/2/Shared%20signature%20of%20recent%20positive%20selection%20on%20the%20TSBP1-BTNL2-HLA-DRA%20genes%20in%20five%20native%20populations%20from%20North%20Borneo%20Fulltext.pdf Hoh, Boon Peng and Xiaoxi Zhang and Lian Deng and Kai Yuan and Yew, Chee Wei and Saw, Woei Yuh and Mohammad Zahirul Hoque and Farhang Aghakhanian and Maude E. Phipps and Vijay Kumar Subbiah and Xu, Shu hua (2020) Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo. Genome biology and evolution, 12 (12). pp. 2245-2257. ISSN 1759-6653 https://doi.org/10.1093/gbe/evaa207 https://doi.org/:10.1093/gbe/evaa207 https://doi.org/:10.1093/gbe/evaa207 |
| spellingShingle | R Medicine (General) Hoh, Boon Peng Xiaoxi Zhang Lian Deng Kai Yuan Yew, Chee Wei Saw, Woei Yuh Mohammad Zahirul Hoque Farhang Aghakhanian Maude E. Phipps Vijay Kumar Subbiah Xu, Shu hua Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo |
| title | Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo |
| title_full | Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo |
| title_fullStr | Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo |
| title_full_unstemmed | Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo |
| title_short | Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo |
| title_sort | shared signature of recent positive selection on the tsbp1-btnl2-hla-dra genes in five native populations from north borneo |
| topic | R Medicine (General) |
| url | https://eprints.ums.edu.my/id/eprint/27521/1/Shared%20Signature%20of%20Recent%20Positive%20Selection%20on%20the%20abstract.pdf https://eprints.ums.edu.my/id/eprint/27521/2/Shared%20signature%20of%20recent%20positive%20selection%20on%20the%20TSBP1-BTNL2-HLA-DRA%20genes%20in%20five%20native%20populations%20from%20North%20Borneo%20Fulltext.pdf https://eprints.ums.edu.my/id/eprint/27521/ https://doi.org/10.1093/gbe/evaa207 https://doi.org/:10.1093/gbe/evaa207 https://doi.org/:10.1093/gbe/evaa207 |
| url_provider | http://eprints.ums.edu.my/ |