Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma
Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the g...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en en |
| Published: |
Springer Nature
2021
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/26723/1/Abstract-Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf https://eprints.ums.edu.my/id/eprint/26723/2/Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf https://eprints.ums.edu.my/id/eprint/26723/ https://doi.org/10.1007/s12328-021-01409-3 |
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| Summary: | Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the gastrointestinal (GI) tract, lymph nodes, and skin. We experience a 74-year-old male who presented with abdominal discomfort, altered bowel habit, loss of weight, and loss of appetite with a palpable abdominal mass. Upper endoscopy revealed multiple dish-like and raised nodular mass with a central ulcer in the stomach and duodenum. The histology was consistent with high-grade lymphoma of the plasmablastic type. The immunohistochemistry was positive for plasma cells marker of CD38 and CD138, but negative for the lymphocytic marker of CD45, as well as mature T and B cell marker of CD3 and CD20. Unfortunately, the patient succumbed due to sepsis without completion of his investigations and treatments. |
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