Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis
A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A−K (1−11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulari...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/25477/1/Sinulaflexiolide%20P%2C%20a%20cembrane-type%20diterpenoid%20from%20the%20Bornean%20soft%20coral%20Sinularia%20flexibilis.pdf https://eprints.ums.edu.my/id/eprint/25477/ https://doi.org/10.1007/s10600-019-02668-w |
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| Summary: | A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A−K (1−11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 μM, respectively. |
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