Insulin resistance and pancreatic β cell mass as the potential predictors of diabetes mellitus among adolescents of economically challenged rural communities in Sabah
Insulin resistance is associated with components of metabolic syndrome. It can be detected many years prior to the development of diabetes, hypertension, dyslipidemia and atherosclerosis in adult life. The transition period from adolescence to adult life is an important period where the modificatio...
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| Summary: | Insulin resistance is associated with components of metabolic syndrome. It can be detected many years prior to the development of diabetes, hypertension, dyslipidemia and
atherosclerosis in adult life. The transition period from adolescence to adult life is an important period where the modification of life style to reduce insulin resistance can be effectively performed to reduce the future morbidity and mortality related to insulin resistance. There are no previous study regarding the status of insulin resistance and
pancreatic β cell mass in adolescents of economically challenged rural communities in Sabah. In this study adolescents from the villages in Sabah who gave informed consent were included and their body mass index, waist circumference, hip circumference, waist hip ratio and blood pressure were examined. Fasting serum insulin and plasma glucose level were determined and insulin resistance and percentage of β cell mass were assessed by using the Homeostasis assessment model (HOMA-IR and HOMA β cell mass). We investigated the relationships between fasting insulin level, fasting blood sugar, BMI, waist circumference, WHR, HOMA IR and HOMA β cell mass in our study. Insulin resistance (HOMA -IR) was found in 3% of study population and 5.7% of female study population. Female genders had the higher risk of insulin resistance compared to male population. |
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