The Flavokawains: Uprising Medicinal Chalcones
lant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been don...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
BioMed Central
2013
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/5209/1/fist-2013-nadeem-artFlavokawainsUprising.pdf http://umpir.ump.edu.my/id/eprint/5209/ http://dx.doi.org/10.1186/1475-2867-13-102 |
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| Summary: | lant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported. |
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