Transdermal drug delivery system through polymeric microneedle: A recent update
As non-toxic, biodegradable, biocompatible materials, the polymeric microneedles have a great significance in terms of delivering therapeutic drug molecules through the skin. They provide several advantages like easy of fabrication, overall less manufacturing cost, a higher amount of drug loading wi...
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| Format: | Article |
| Language: | en |
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Elsevier B.V.
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/29111/1/Transdermal%20drug%20delivery%20system%20through%20polymeric%20microneedle1.pdf http://umpir.ump.edu.my/id/eprint/29111/ https://doi.org/10.1016/j.jddst.2020.101877 |
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| author | Azmana, Motia Mahmood, Syed Hilles, A. R. Mandal, Uttam Kumar AL-japairai, Khater Ahmed Saeed Subashini, Raman |
| author_facet | Azmana, Motia Mahmood, Syed Hilles, A. R. Mandal, Uttam Kumar AL-japairai, Khater Ahmed Saeed Subashini, Raman |
| author_sort | Azmana, Motia |
| building | UMPSA Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaysia Pahang Al-Sultan Abdullah |
| content_source | UMPSA Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | As non-toxic, biodegradable, biocompatible materials, the polymeric microneedles have a great significance in terms of delivering therapeutic drug molecules through the skin. They provide several advantages like easy of fabrication, overall less manufacturing cost, a higher amount of drug loading with desired controlled release profile. Transdermal drug delivery through microneedles system has witnessed a great deal of advancement; few products have been launched in the market. However, the enormous potential of the same is still awaiting to be flourished to its full potential. Among the various types of microneedles, polymeric microneedles appear to be promising due to their inherent favourable attributes. This review describes the key features of the polymeric microneedles, such as their current update and marketed products, mechanism, kinetics, fabrication techniques, materials used, classifications, evaluation, applications, and future challenges. It also highlights a guideline for polymer selection concerning the recent design and intended use for delivering the drug through the transdermal route. Additionally, this review sheds light to clinical perspective, future scope, and direction of polymeric microneedles as a transdermal drug delivery system. |
| format | Article |
| id | my.ump.umpir.29111 |
| institution | Universiti Malaysia Pahang |
| language | en |
| publishDate | 2020 |
| publisher | Elsevier B.V. |
| record_format | eprints |
| spelling | my.ump.umpir.291112021-09-03T07:28:22Z http://umpir.ump.edu.my/id/eprint/29111/ Transdermal drug delivery system through polymeric microneedle: A recent update Azmana, Motia Mahmood, Syed Hilles, A. R. Mandal, Uttam Kumar AL-japairai, Khater Ahmed Saeed Subashini, Raman TP Chemical technology As non-toxic, biodegradable, biocompatible materials, the polymeric microneedles have a great significance in terms of delivering therapeutic drug molecules through the skin. They provide several advantages like easy of fabrication, overall less manufacturing cost, a higher amount of drug loading with desired controlled release profile. Transdermal drug delivery through microneedles system has witnessed a great deal of advancement; few products have been launched in the market. However, the enormous potential of the same is still awaiting to be flourished to its full potential. Among the various types of microneedles, polymeric microneedles appear to be promising due to their inherent favourable attributes. This review describes the key features of the polymeric microneedles, such as their current update and marketed products, mechanism, kinetics, fabrication techniques, materials used, classifications, evaluation, applications, and future challenges. It also highlights a guideline for polymer selection concerning the recent design and intended use for delivering the drug through the transdermal route. Additionally, this review sheds light to clinical perspective, future scope, and direction of polymeric microneedles as a transdermal drug delivery system. Elsevier B.V. 2020 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/29111/1/Transdermal%20drug%20delivery%20system%20through%20polymeric%20microneedle1.pdf Azmana, Motia and Mahmood, Syed and Hilles, A. R. and Mandal, Uttam Kumar and AL-japairai, Khater Ahmed Saeed and Subashini, Raman (2020) Transdermal drug delivery system through polymeric microneedle: A recent update. Journal of Drug Delivery Science and Technology, 60 (101877). pp. 1-13. ISSN 1773-2247. (Published) https://doi.org/10.1016/j.jddst.2020.101877 https://doi.org/10.1016/j.jddst.2020.101877 |
| spellingShingle | TP Chemical technology Azmana, Motia Mahmood, Syed Hilles, A. R. Mandal, Uttam Kumar AL-japairai, Khater Ahmed Saeed Subashini, Raman Transdermal drug delivery system through polymeric microneedle: A recent update |
| title | Transdermal drug delivery system through polymeric microneedle: A recent update |
| title_full | Transdermal drug delivery system through polymeric microneedle: A recent update |
| title_fullStr | Transdermal drug delivery system through polymeric microneedle: A recent update |
| title_full_unstemmed | Transdermal drug delivery system through polymeric microneedle: A recent update |
| title_short | Transdermal drug delivery system through polymeric microneedle: A recent update |
| title_sort | transdermal drug delivery system through polymeric microneedle: a recent update |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/29111/1/Transdermal%20drug%20delivery%20system%20through%20polymeric%20microneedle1.pdf http://umpir.ump.edu.my/id/eprint/29111/ https://doi.org/10.1016/j.jddst.2020.101877 https://doi.org/10.1016/j.jddst.2020.101877 |
| url_provider | http://umpir.ump.edu.my/ |