Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model
The objective of this study is to estimate total plasma insulin level and endogenous insulin secretion by using Intensive Control Insulin-Nutrition-Glucose (ICING) model and 90 critically ill patients’ data from Hospital Tengku Ampuan Afzan, Kuantan. Integral-based method was applied to solve mathem...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
American Scientific Publishers
2017
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/19702/7/fkm-2016-ummu-Estimation%20of%20Plasma%20Insulin%20and%20Endogenous.pdf http://umpir.ump.edu.my/id/eprint/19702/ https://doi.org/10.1166/asl.2017.7410 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1831525208254578688 |
|---|---|
| author | Ummu Kulthum, Jamaludin Fatanah, M. Suhaimi Normy Norfiza, A. Razak Azrina, M. Ralib Mohd Basri, Mat Nor |
| author_facet | Ummu Kulthum, Jamaludin Fatanah, M. Suhaimi Normy Norfiza, A. Razak Azrina, M. Ralib Mohd Basri, Mat Nor |
| author_sort | Ummu Kulthum, Jamaludin |
| building | UMPSA Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaysia Pahang Al-Sultan Abdullah |
| content_source | UMPSA Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | The objective of this study is to estimate total plasma insulin level and endogenous insulin secretion by using Intensive Control Insulin-Nutrition-Glucose (ICING) model and 90 critically ill patients’ data from Hospital Tengku Ampuan Afzan, Kuantan. Integral-based method was applied to solve mathematical equations defined in ICING model to find critical parameters of insulin sensitivity (SI) and results of total endogenous insulin secretion and total plasma insulin level were presented in median and 95% confidence interval (CI). It is reported that the total median plasma insulin is 1.35 x 106 mU while (6.59 x 105, 2.79 x 106) mU is in 95% CI, and the total median endogenous insulin secretion is 12.9% from the total median plasma insulin. The results elucidated the effectiveness of current practice via Intensive Insulin Infusion Therapy (IIT) and also suggest a further study on investigating the incretin mechanism which is strongly believed to contribute to the total plasma insulin level and help to simulate endogenous insulin secretion. |
| format | Article |
| id | my.ump.umpir.19702 |
| institution | Universiti Malaysia Pahang |
| language | en |
| publishDate | 2017 |
| publisher | American Scientific Publishers |
| record_format | eprints |
| spelling | my.ump.umpir.197022018-11-30T02:01:32Z http://umpir.ump.edu.my/id/eprint/19702/ Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model Ummu Kulthum, Jamaludin Fatanah, M. Suhaimi Normy Norfiza, A. Razak Azrina, M. Ralib Mohd Basri, Mat Nor QA Mathematics T Technology (General) TJ Mechanical engineering and machinery The objective of this study is to estimate total plasma insulin level and endogenous insulin secretion by using Intensive Control Insulin-Nutrition-Glucose (ICING) model and 90 critically ill patients’ data from Hospital Tengku Ampuan Afzan, Kuantan. Integral-based method was applied to solve mathematical equations defined in ICING model to find critical parameters of insulin sensitivity (SI) and results of total endogenous insulin secretion and total plasma insulin level were presented in median and 95% confidence interval (CI). It is reported that the total median plasma insulin is 1.35 x 106 mU while (6.59 x 105, 2.79 x 106) mU is in 95% CI, and the total median endogenous insulin secretion is 12.9% from the total median plasma insulin. The results elucidated the effectiveness of current practice via Intensive Insulin Infusion Therapy (IIT) and also suggest a further study on investigating the incretin mechanism which is strongly believed to contribute to the total plasma insulin level and help to simulate endogenous insulin secretion. American Scientific Publishers 2017-06-01 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19702/7/fkm-2016-ummu-Estimation%20of%20Plasma%20Insulin%20and%20Endogenous.pdf Ummu Kulthum, Jamaludin and Fatanah, M. Suhaimi and Normy Norfiza, A. Razak and Azrina, M. Ralib and Mohd Basri, Mat Nor (2017) Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model. Advanced Science Letters, 23 (6). pp. 5511-5514. ISSN 1936-6612. (Published) https://doi.org/10.1166/asl.2017.7410 https://doi.org/10.1166/asl.2017.7410 |
| spellingShingle | QA Mathematics T Technology (General) TJ Mechanical engineering and machinery Ummu Kulthum, Jamaludin Fatanah, M. Suhaimi Normy Norfiza, A. Razak Azrina, M. Ralib Mohd Basri, Mat Nor Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model |
| title | Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model |
| title_full | Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model |
| title_fullStr | Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model |
| title_full_unstemmed | Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model |
| title_short | Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model |
| title_sort | estimation of plasma insulin and endogenous insulin secretion in critically ill patients using icing model |
| topic | QA Mathematics T Technology (General) TJ Mechanical engineering and machinery |
| url | http://umpir.ump.edu.my/id/eprint/19702/7/fkm-2016-ummu-Estimation%20of%20Plasma%20Insulin%20and%20Endogenous.pdf http://umpir.ump.edu.my/id/eprint/19702/ https://doi.org/10.1166/asl.2017.7410 https://doi.org/10.1166/asl.2017.7410 |
| url_provider | http://umpir.ump.edu.my/ |