Optimisation of Solid Liquid Extraction of Orthosiphon stamineus Leaves using Response Surface Methodology Technique
Orthosiphon stamineus is one of the popular medicinal plants in Southeast Asia. O. stamineus leaves are used in numerous applications related to medicinal purposes and are believed to cure certain health conditions such as hypertension, gout and fever. The aim of this study was to investigate the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en en |
| Published: |
Universiti Putra Malaysia Press
2015
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/11334/1/Optimisation%20of%20Solid%20Liquid%20Extraction%20of%20Orthosiphon%20stamineus%20Leaves%20using%20Response%20Surface%20Methodology%20Technique.pdf http://umpir.ump.edu.my/id/eprint/11334/7/Optimisation%20of%20Solid%20Liquid%20Extraction%20of%20Orthosiphon%20stamineus%20Leaves%20using%20Response%20Surface%20Methodology%20Technique.pdf http://umpir.ump.edu.my/id/eprint/11334/ http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2038%20(2)%20May.%202015/08%20Page%20259-270%20(JTAS%200607-2014).pdf |
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| Summary: | Orthosiphon stamineus is one of the popular medicinal plants in Southeast Asia. O.
stamineus leaves are used in numerous applications related to medicinal purposes and are
believed to cure certain health conditions such as hypertension, gout and fever. The aim of
this study was to investigate the effect of three parameters involved in extraction process
including extraction temperature, extraction duration and solvent to solid ratio on extraction
yield, antioxidant activity and referral markers of O. stamineus leaves. The optimisation of
extraction processes was evaluated with the aid of Design-Expert software using response
surface methodology (RSM). The optimum extraction parameter for O. stamineus leaves
were recorded at the extraction temperature of 60°C, 30:1 (ml:g) solvent to solid ratio and 6
hours extraction duration with 30Wt% extract, 67 and 1 mg/L concentration of Rosmarinic
acid and Sinensetin, respectively. Antioxidant activity for optimized extract is 96.56% and
91.51% of SOD and DPPH method, respectively. |
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